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Implantable Organic Nano-Electronics

Objective

The vision of iONE-FP7 is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will (a) have long-term stability associated to high biocompatibility and safety, (b) have reduced risk of a host versus graft immune response, (c) mimic the local microenvironment for stem/precursor cell recruitment and differentiation, (d) monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies (e) perform local stimulation with tunable electric fields, (f) deliver locally growth factors, neurotransmitters, and drugs.

The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nanoparticle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response.

The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the iONE-FP7 device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogeneous stem cells by implanting the iONE-FP7 device into a contusion SCI animal model.

iONE-FP7 will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /humanities/arts/modern and contemporary art/film

Call for proposal

FP7-NMP-2011-SMALL-5
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Address
Via Universita 4
41121 Modena
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 180 885,74
Administrative Contact
Daniela Quaglino (Prof.)

Participants (12)

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 586 685,45
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Giuseppina Padeletti (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 469 894,80
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaffer (Ms.)
SCRIBA NANOTECNOLOGIE SRL
Italy
EU contribution
€ 445 937
Address
Via Di Corticella 183/8
40128 Bologna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrizia Alessandra Fulle (Dr.)
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 372 595,20
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sophie Lindesvik (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 372 996
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jimenez Arroyo (Mr.)
UNIVERSIDADE DO ALGARVE
Portugal
EU contribution
€ 210 712
Address
Campus De Penha
8005 139 Faro
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Henrique Leonel Gomes (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 382 904
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Gilles Pulvermuller (Mr.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 363 180
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Zerbetto (Prof.)
POLYGANICS INNOVATIONS BV

Participation ended

Netherlands
EU contribution
€ 20 790,81
Address
Rozenburglaan 15 A
9727 DL Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robbert De Graaf (Dr.)
STMICROELECTRONICS SRL

Participation ended

Italy
EU contribution
€ 116 695
Address
Via C.olivetti 2
20864 Agrate Brianza
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maria Grazia Podesta' (Dr.)
AMIRES SARL
Switzerland
EU contribution
€ 130 300
Address
Rue De La Serre 4
2000 Neuchatel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rudolf Frycek (Dr.)
CONTIPRO BIOTECH SRO
Czechia
EU contribution
€ 180 760
Address
Dolni Dobrouc 401
56102 Dolni Dobrouc
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vladimir Velebny (Mr.)