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Dengue research Framework for Resisting Epidemics in Europe

Dengue research Framework for Resisting Epidemics in Europe

Objective

"WHO estimates that one of the main consequences of global warming will be an increased burden of vector-borne diseases. Among these, dengue appears to be particularly problematic, with tens of millions of cases of dengue fever estimated to occur annually, including up to 500,000 cases of the life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent years, the global burden of dengue disease has been rising dramatically and this prolific increase has been connected to societal changes such as population growth, urbanization and the transport of infected hosts and vectors. In addition, rising temperatures and global climate change may lead to the expansion of the range of major mosquito vectors, extension of the transmission season in areas with currently circulating dengue virus and increase in the mosquito spp. vectorial capacity. Active surveillance to detect in-coming dengue virus (DENV) in regions at the limits of DENV circulation are an important initial step in the prevention of dengue epidemics in Europe. Asymptomatic infections likely play a crucial role in the initial invasion process and DENV transmission and, although hitherto ignored, must be addressed.
Using retrospective and prospective data from Asia, the main objectives of the program are (1) to identify key factors determining dengue transmission, outcome of infection and epidemics; (2) the development of novel diagnostic tools to detect asymptomatic infections. We will estimate the risk of DENV spreading to uninfected areas, especially in Southern Europe where susceptible vector exists. The major tools generated will be predictive models that enable specific interventions to reduce epidemic probability and diagnostic methods for surveillance. Inherent in this approach is the belief that improved surveillance and diagnosis of the asymptomatic dengue carriers will contribute to effective intervention, especially during early stages of pathogen invasion into a naïve region."
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Coordinator

INSTITUT PASTEUR

Address

Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

France

Activity type

Research Organisations

EU Contribution

€ 1 396 860,04

Administrative Contact

Sophie Ablott (Mrs.)

Participants (14)

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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 429 791,80

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN

Germany

EU Contribution

€ 336 560

MAHIDOL UNIVERSITY

Thailand

EU Contribution

€ 574 280

INSTITUT PASTEUR DU CAMBODGE FOUNDATION

Cambodia

EU Contribution

€ 821 504,20

FUNDACIO INSTITUT CATALA DE CIENCIES DEL CLIMA

Spain

EU Contribution

€ 399 304,50

UNIVERSITE DE ROUEN NORMANDIE

France

EU Contribution

€ 356 800

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 236 168

FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP

Portugal

EU Contribution

€ 288 000

IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP

Portugal

EU Contribution

€ 267 600

BIOCOMPUTING PLATFORMS LTD OY

Finland

EU Contribution

€ 213 960

AMPTEC GMBH

Germany

EU Contribution

€ 324 480

RIOTECH PHARMACEUTICALS LTD

United Kingdom

EU Contribution

€ 204 480

INSTITUTO DE MEDICINA TROPICAL PEDRO KOURI

Cuba

EU Contribution

€ 109 273,46

INSTITUT LOUIS MALARDE

French Polynesia

EU Contribution

€ 40 000

Project information

Grant agreement ID: 282378

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 December 2016

Funded under:

FP7-HEALTH

  • Overall budget:

    € 8 373 688,07

  • EU contribution

    € 5 999 062

Coordinated by:

INSTITUT PASTEUR

France