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Biomaterials for Tracheal Replacement in Age-related Cancer via a Humanly Engineered Airway

Objective

Age-related cancers, especially of the trachea, are neoplastic lesions that significantly impact upon the lives of thousands of European patients each year. Unfortunately, most present with inoperable lesions for which median survival is less than 12 months. Based on our previous clinically successful experiences with in vivo completely tissue engineered tracheal replacement in benign tracheal diseases, we recently applied this technology in 2 patients with otherwise inoperable primary tracheal cancers. The successful observed outcome confirms the unique opportunity to scale-up an effective therapeutic approach into a widely accessible clinical technology, which could enhance not only the quality of life but even cure otherwise untreatable patients. However, a limitation of our current technology is the time it takes to re-populate the decellularized trachea. This may prove critical in the case of cancer patients. Further, the size of the transplant is currently limited due to the fact that the transplanted tissue needs to be efficiently and rapidly vascularised to prevent necrosis in vivo. To surmount these limitations, we aim to: i) improve our current technique of in vivo tissue engineering human tracheae in a small number of patients and subsequently begin a formal clinical trial, ii) develop pharmacological approaches to activate endogenous stem cells, stimulate tissue regeneration and vascularisation in situ, iii) develop a synthetic tracheal scaffold using a novel nanocomposite polymer as alternatives to natural human scaffolds and iv) develop good medical practice manufacturing process for safe, efficient and cost effective commercial production. This research project is aimed to define a robust airway implantation technique assuring a better outcome for thousands of patients each year. Moreover, we aim to use these results as a starting point to develop clinical approaches that could improve the treatment of age-related cancers of other hollow organs.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /engineering and technology/industrial biotechnology/biomaterials
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-NMP-2011-SMALL-5
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project
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Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 173 842
Administrative Contact
Ylva Hultman (Ms.)

Participants (12)

UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 181 680
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Doris Stefanowa (Dr.)
University College London
United Kingdom
EU contribution
€ 695 800
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 366 000
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Dr.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU contribution
€ 400 750
Address
Via Universita 4
41121 Modena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Graziella Pellegrini (Prof.)
AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI

Participation ended

Italy
EU contribution
€ 20 900
Address
Via Delle Oblate 1
50139 Firenze
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paolo Macchiarini (Prof.)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 80 400
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
Administrative Contact
Arnauld Forest (Dr.)
ROBERT KOCH-INSTITUT
Germany
EU contribution
€ 60 000
Address
Nordufer 20
13353 Berlin
Activity type
Research Organisations
Administrative Contact
Birgit Arnold (Ms.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 205 428
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Loredana De Bartolo (Dr.)
CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI
Italy
EU contribution
€ 208 800
Address
Via Giusti 9
50121 Firenze
Activity type
Research Organisations
Administrative Contact
Daniele Consigli (Mr.)
INTERCYTEX LTD
United Kingdom
EU contribution
€ 192 000
Address
Crewe Road Innovation House
M23 9QR Manchester
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paula Thompson (Ms.)
Pharmidex Pharmaceutical Services Limited
United Kingdom
EU contribution
€ 124 500
Address
Hanover Street 14 Floor 3
W1S 1RR London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mo Alavijeh (Dr.)
HUGO SACHS ELEKTRONIK - HARVARD APPARATUS GMBH
Germany
EU contribution
€ 289 200
Address
Grunstrasse 1
79232 March Hugstetten
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roger Zink (Dr.)