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Mucus Permeating Nanoparticulate Drug Delivery Systems

Objective

The objective of the ALEXANDER project is the identification of novel strategies (e.g., proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g., disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g., intestinal, nasal, ocular, vaginal, buccal, pulmonary). In particular, R&D activities will be focused on the synthesis of functionalized nanocarriers capable of permeating the mucus gel layer and delivering their therapeutic payload to the epithelium. The nanocarriers will be characterized with respect to their physicochemical properties, ability to cross the mucus gel layer, in vitro and in vivo cytotoxicity. The potential of the developed nanocarriers as delivery systems for mucosal administration of macromolecules will be demonstrated via the oral delivery of peptides, oligosaccharides and oligonucleotides and the nasal delivery of a plasmid encoding for an antigen.

Call for proposal

FP7-NMP-2011-LARGE-5
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Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V.
Address
Theodor Heuss Allee 25
60486 Frankfurt
Germany
Activity type
Research Organisations
EU contribution
€ 1 015 908,63
Administrative Contact
Andreas Förster (Dr.)

Participants (18)

UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 692 998,80
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Bernkop-Schnuerch (Prof.)
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 580 744,40
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georgia Petridou (Ms.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 633 211,20
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aleona Blinova (Ms.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 288 002,90
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nick Bodycombe (Mr.)
UNIVERSIDAD DE NAVARRA
Spain
EU contribution
€ 728 634,80
Address
Campus Universitario Edificio Central
31080 Pamplona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Iñigo Uriarte Pueyo (Dr.)
INSTITUT JOZEF STEFAN
Slovenia
EU contribution
€ 565 000
Address
Jamova 39
1000 Ljubljana
Activity type
Research Organisations
Administrative Contact
Jadran Lenarcic (Prof.)
EVONIK INDUSTRIES AG

Participation ended

Germany
EU contribution
€ 376 949,50
Address
Rellinghauser Strasse 1-11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rosario Lizio (Dr.)
LEK FARMACEVTSKA DRUZBA DD
Slovenia
EU contribution
€ 343 997
Address
Verovskova Ulica 57
1526 Ljubljana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Janez Kerc (Dr.)
CROMA-PHARMA GMBH

Participation ended

Austria
EU contribution
€ 80 668,27
Address
Industrizeile 6
2100 Leobendorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christian Huber (Mr.)
NANOMI BV

Participation ended

Netherlands
EU contribution
€ 119 835
Address
Zutphenstraat 51
7575 EJ Oldenzaal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gert Veldhuis (Dr.)
THIOMATRIX FORSCHUNGS UND BERATUNGS GMBH
Austria
EU contribution
€ 718 986
Address
Unterer Platz 22
9300 St Veit An Der Glan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andreas Bernkop-Schnürch (Prof.)
SAGETIS BIOTECH SL
Spain
EU contribution
€ 769 063,20
Address
Via Augusta 390
08017 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eduard Diviu Terradas (Mr.)
MERCK SERONO SPA

Participation ended

Italy
Address
Via Casilina 125
00176 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniel Leblanc (Mr.)
UNIVERSITY OF GREENWICH
United Kingdom
EU contribution
€ 472 130,96
Address
Old Royal Naval College, Park Row, Greenwich
SE10 9LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alison Yakub (Ms.)
BOEHRINGER INGELHEIM INTERNATIONALGMBH

Participation ended

Germany
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pascal Badalucco
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 388 332,34
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Timo Hartikainen (Dr.)
EVONIK NUTRITION & CARE GMBH
Germany
EU contribution
€ 207 639
Address
Rellinghauser Strasse 1 11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mark Knochenhauer
BOEHRINGER INGELHEIM PHARMA GMBH &CO KG
Germany
EU contribution
€ 116 100
Address
Binger Strasse 173
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Jung (Dr.)