Cel The African naked mole-rat (Heterocephalus glaber) is an unusual rodent species that has evolved physiological strategies to adapt to an extreme ecological niche. It is the only poikilothermic mammal (cold-blooded), has an extraordinarily long life span for its small size (in excess of 30 years) and lives in large colonies organized like those of termites (eusocial). We have shown that naked mole-rats lack physiological attributes thought essential and protective for most other animal species. For example, severe tissue acidosis is life threatening as well as painful and yet naked mole-rats completely lack behavioral sensitivity to acid and sensory neurons are not activated by protons in this species. Here we will identify functionally important naked mole-rat gene variants that may account for aspects of the extreme physiology in this species. We have already identified candidate naked mole-rat-genes whose altered function, compared to other mammals, may account for acid insensitivity, lack of pain sensitization and poikilothermy in this species. These gene variants will be functionally characterized by replacing the mouse gene with a naked-mole rat variant using molecular genetic techniques. In addition we will use next generation sequencing to identify further naked mole-rat gene variants. These studies will allow us to learn how evolution selected for functionally significant gene variants that can radically alter normal physiology in the context of a rodent genome. Dziedzina nauki medical and health sciencesbasic medicinephysiologynatural sciencesbiological scienceszoologymammalogynatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS5 - ERC Advanced Grant - Neurosciences and neural disorders Zaproszenie do składania wniosków ERC-2011-ADG_20110310 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Wkład UE € 2 498 960,00 Adres ROBERT ROSSLE STRASSE 10 13125 Berlin Niemcy Zobacz na mapie Region Berlin Berlin Berlin Rodzaj działalności Research Organisations Kontakt administracyjny Ioannis Legouras (Dr.) Kierownik naukowy Gary Richard Lewin (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Niemcy Wkład UE € 2 498 960,00 Adres ROBERT ROSSLE STRASSE 10 13125 Berlin Zobacz na mapie Region Berlin Berlin Berlin Rodzaj działalności Research Organisations Kontakt administracyjny Ioannis Legouras (Dr.) Kierownik naukowy Gary Richard Lewin (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych