CORDIS
Forschungsergebnisse der EU

CORDIS

Deutsch DE

A modular micro nuclear magnetic resonance in vivo platform for the nematode Caenorhabditis elegans

Projektinformationen

ID Finanzhilfevereinbarung: 290586

Status

Abgeschlossenes Projekt

  • Startdatum

    1 Juli 2012

  • Enddatum

    30 Juni 2017

Finanziert unter:

FP7-IDEAS-ERC

  • Gesamtbudget:

    € 3 396 960

  • EU-Beitrag

    € 3 396 960

Veranstaltet durch:

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Deutschland

Ziel

"Using state-of-the-art microsystems simulation, design and micro-engineering, the NMCEL project will result in a highly integrated and modular and low cost platform that is a high throughput micro-fluidic lab-on-a-chip and a sophisticated nuclear magnetic resonance (NMR) detector in one package, suitable for use in a wide-bore commercial NMR magnet. This unique platform targets the controlled in vivo NMR spectroscopy and imaging of the model organism C. elegans, for this purpose the high throughput micro-fluidic lab-on-a-chip has the necessary infrastructure to feed, hold, move and immobilise a large population of C. elegans on demand and over its lifecycle and lifetime, with operations synchronised with the remaining functions of the platform. In turn, the co-integrated NMR detector is specially adapted to the range of shapes of the nematode, and its motility, and is optimised with regard to NMR signal-to-noise ratio and spectral resolution. In order to attain high resolution, the NMR system is optimised for strong magnetic fields, through the computed layout of devices, the adaptation of microstructurable materials, and the design of electronics and control circuits. The targeted user of the platform is a C. elegans micro-biologist with a requirement to detect or discover small molecule (< 1000 Da) metabolites in vivo. High throughput in vivo metabolomic mapping, with a platform that generates molecular data on an individual-by-individual basis for populations of thousands of individuals, has the potential to open up a completely new window of research in systems biology. The NMCEL project aims to address this important step ahead."
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Hauptforscher

Jan Gerrit Korvink (Prof.)

Gastgebende Einrichtung

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Adresse

Kaiserstrasse 12
76131 Karlsruhe

Deutschland

Aktivitätstyp

Higher or Secondary Education Establishments

EU-Beitrag

€ 1 433 403,80

Hauptforscher

Jan Gerrit Korvink (Prof.)

Kontakt Verwaltung

Kronimus Berndt (Dr.)

Begünstigte (2)

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Deutschland

EU-Beitrag

€ 1 433 403,80

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Deutschland

EU-Beitrag

€ 1 963 556,20

Projektinformationen

ID Finanzhilfevereinbarung: 290586

Status

Abgeschlossenes Projekt

  • Startdatum

    1 Juli 2012

  • Enddatum

    30 Juni 2017

Finanziert unter:

FP7-IDEAS-ERC

  • Gesamtbudget:

    € 3 396 960

  • EU-Beitrag

    € 3 396 960

Veranstaltet durch:

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Deutschland