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Sarcomere based Signals in Muscle Remodelling

Objective

The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded into the sarcomere. Thereby, titin and nebuliun with dual structural scaffold and biosensing functions intricately connect the sarcomere to muscle remodelling.
Molecular progress on titin- and nebulin based sarcomeric signalosomes has been accelerated during recent years, and the next step require is a functional understanding regarding how titin and nebulin and associated signaling complexes generate biochemical signals, and how these signals in turn, control muscle trophicity and remodelling. This network addresses this issue by bringing together teams leading in titin and nebulin muscle biology from America, Japan, and the US. Each team will contribute specific resources to study titin- and nebulin-based muscle remodelling, including transgenic animal models, compounds from high-throughput screens, and intricate myofibril mechanics. Importantly, SARCOSI will provide the European researchers resources that are otherwise not available.
While the participants have collaborated and published together occassionally in the past, the SARCOSI network will establish long-term strategic EU transcontinental partnerships by staff exhanges and joint mentoring of thesis and postdoctoral projects. The exchange of staff will enhance the transfer of technologies and models between participating laboratories. By working close together and sharing resources, progress will be achieved much faster than working separately in the clinically important field of pathological muscle remodelling that contributes to both chronic heart failure and to skeletal muscle sarcopenia

Call for proposal

FP7-PEOPLE-2011-IRSES
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Funding Scheme

MC-IRSES - International research staff exchange scheme (IRSES)

Coordinator

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Address
Seminarstrasse 2
69117 Heidelberg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 333 900
Administrative Contact
Siegfried Labeit (Prof.)

Participants (11)

VILNIAUS UNIVERSITETAS
Lithuania
EU contribution
€ 75 600
Address
Universiteto G. 3
01513 Vilnius
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vida Lapinskaite (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Participation ended

United Kingdom
EU contribution
€ 31 500
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 88 200
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Steve Brooks (Dr.)
THE UNIVERSITY OF LIVERPOOL

Participation ended

United Kingdom
EU contribution
€ 37 800
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mark Claridge (Mr.)
UNIVERSITA DEGLI STUDI DI TRIESTE
Italy
EU contribution
€ 142 800
Address
Piazzale Europa 1
34127 Trieste
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marina Cattarini (Dr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Participation ended

Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Philip Seignette (Dr.)
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
EU contribution
€ 33 600
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Michele Marron (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 39 900
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Walker (Mr.)
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 25 200
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefanie Preuss (Dr.)
STICHTING VU
Netherlands
EU contribution
€ 147 000
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Telkamp (Dr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 25 200
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Walker (Mr.)