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New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier

Objective

Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improvement of classical therapies and it would also make a high number of new therapies feasible. To make this happen, the final objective of Trans-INT is to design nanocarriers specifically adapted to deal with the gastrointestinal ecosystem and use them for the development of new oral nanomedicines for diseases with high socioeconomic impact (i.e. metabolic diseases, pain medication).

The concept behind TRANS-INT is the rational design of oral nanomedicines based on safety, mechanistic, bioengineering (multifunctional nanocarriers: high payload, drug protection, efficient drug transport, controlled release) and pharmaceutical technology criteria (scalable technology and stability). The project will start with nanocarrier platforms on which the partners have IPR and freedom to operate: nanocapsules, nanoparticles, micelles made of combinations of lipids, polypeptides and polysaccharides, continue with the optimization and redefinition of selected nanocarriers. It is expected to end with (i) at least one oral nanocarrier prototype with a comprehensive GLP-tox package, which could be applied for the delivery of a high number of peptide molecules, (ii) at least one nanomedicine fulfilling target product profile criteria, with a comprehensive preclinical evaluation package, (iii) substantial integrative knowledge on the feasibility and potential of oral nanocarriers and nanopharmaceuticals. TRANS-INT is expected to have a great impact no only from the new therapies/patients perspective but also from the innovation and EU industrial development perspective.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /medical and health sciences/medical biotechnology/nanomedicine
  • /social sciences/social and economic geography/transport

Call for proposal

FP7-NMP-2011-LARGE-5
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 665 013,76
Administrative Contact
Martin Cacheiro Martinez (Mr.)

Participants (17)

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 654 159,40
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 506 920
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Véronique Préat (Prof.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 355 755,23
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Aloïse Mabondzo (Dr.)
University College London
United Kingdom
EU contribution
€ 699 576
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES S.A

Participation ended

Spain
Address
Calle Baldari I Reixach 10
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vila Pena Ana Isabel (Dr.)
VENETO NANOTECH SOCIETA CONSORTILEPER AZIONI

Participation ended

Italy
EU contribution
€ 117 477,29
Address
Piazza Salvemini 13
35131 Padova
Activity type
Research Organisations
Administrative Contact
Roberta Mitidieri (Ms.)
SIGMOID PHARMA LIMITED
Ireland
EU contribution
€ 390 900
Address
The Invent Centre, Dublin City University
9 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivan S Coulter (Dr.)
UNIVERSITE D'ANGERS
France
EU contribution
€ 558 305,22
Address
Rue De Rennes 40
49035 Angers Cedex 01
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jean-Pierre Benoit (Prof.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 434 880
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain
EU contribution
€ 302 040
Address
Carrer Baldiri Reixac 10-12 Parc Scientific De Barcelona
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Alexandre Puerto Valdivieso (Mr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 449 436,40
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Nises Ahlgren (Ms.)
Participant Legal name Istituto Oncologico Veneto IRCCS
Italy
EU contribution
€ 301 400
Address
Via Gattamelata
35128 Padova
Activity type
Research Organisations
Administrative Contact
Manuela Mtanis (Ms.)
SEROSCIENCE LTD
Hungary
EU contribution
€ 346 320
Address
Csabai Kapu 20
3529 Miskolc
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Janos Csukás (Mr.)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 616 154
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Denis Croisat (Dr.)
F. HOFFMANN-LA ROCHE AG

Participation ended

Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barbara Lueckel (Dr.)
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 459 100
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
Administrative Contact
David O'connell (Dr.)
ECAMRICERT SRL
Italy
EU contribution
€ 142 562,70
Address
Viale Del Lavoro 6
36030 Monte Di Malo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicola Dalle Molle (Dr.)