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VitaminD3-Omega3-Home Exercise- HeALTHy Ageing and Longevity Trial

Objective

As the European population is ageing rapidly, the growing number of seniors with age-related chronic diseases poses a challenge on European societies and health care systems. Therapeutic interventions that are effective, affordable and well-tolerated in the prevention of chronic disease are urgently needed and will have an outstanding impact on public health as a whole. Among the most promising interventions that meet these requirements are vitamin D, marine omega-3 fatty acids and physical exercise. However, their individual and combined effects have yet to be confirmed in a clinical trial. The DO-HEALTH will close this knowledge gap in a large 3-year multi-centre clinical trial that will establish long-term efficacy and safety data for the 3 interventions in the prevention of age-related diseases in seniors.
The DO-HEALTH trial will enrol 2152 community-dwelling men and women aged 70 and older, when chronic diseases increase substantially. The randomized-controlled trial will test the individual and the combined benefit of 2000 IU vitamin D/day, 1 g of omega-3 fatty acids/day and a simple home exercise program in an efficient factorial trial design. DO-HEALTH will establish evidence in 5 primary endpoints: the risk of incident non-vertebral fractures; the risk of functional decline; the risk of blood pressure increase; the risk of cognitive decline; and the rate of any infection. Key secondary endpoints include risk of hip fracture, rate of falls, pain in symptomatic knee osteoarthritis, glucose tolerance, gastro-intestinal symptoms, mental and oral health, quality of life, and mortality. Follow-up will be in-person, in 3-monthly intervals (4 clinical visits and 9 phone calls). DO-HEALTH will further assess the comparative effectiveness of the interventions by evaluating reasons why or why not seniors adhere to them, and will assess their cost-benefit in a health economic model based on documented health care utilization and observed incidence of chronic disease.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

University of Zurich
Address
Ramistrasse 71
8006 Zurich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 479 647,75
Administrative Contact
Heike Bischoff-Ferrari (Prof.)

Participants (23)

FERRARI STEPHEN MARIO

Participation ended

Switzerland
Address
Feldguetliweg 152
8706 Feldmeilen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stephen Ferrari (Mr.)
NOVAMEN SAS

Participation ended

France
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vincent Grosbois (Mr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 368 950
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvan Seguin (Mr.)
UNIVERSITATSSPITAL BASEL

Participation ended

Switzerland
EU contribution
€ 5 726,40
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Reto W. Kressig (Prof.)
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
France
EU contribution
€ 704 093
Address
Rue Viguerie 2 Hotel Dieu Saint Jacques
31052 Toulouse Cedex 3
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Odile Sechoy-Balussou (Dr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 798 125,08
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fraßdorf (Ms.)
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG

Participation ended

Germany
EU contribution
€ 15 416,17
Address
Schlossplatz 4
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Hoffmann (Ms.)
MAX RUBNER INSTITUT BUNDESFORSCHUNGSINSTITUT FUR ERNAEHRUNG UND LEBENSMITTEL
Germany
EU contribution
€ 67 500
Address
Haid Und Neu Strasse 9
76131 Karlsruhe
Activity type
Research Organisations
Administrative Contact
Juergen Wagner (Mr.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 358 450
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sonja Schimdl (Dr.)
UNIVERSIDADE DE COIMBRA
Portugal
EU contribution
€ 677 031
Address
Paco Das Escolas
3001 451 Coimbra
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sérgio Paulo Da Conceição Vicente (Dr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 44 318
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katherine Boylan (Dr.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 37 568
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joanne Watson (Ms.)
INTERNATIONAL OSTEOPOROSIS FOUNDATION
Switzerland
EU contribution
€ 30 000
Address
Rue Juste Olivier 9
1260 Nyon
Activity type
Other
Administrative Contact
John Kanis (Prof.)
ACIES Consulting Group SAS
France
EU contribution
€ 180 000
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vincent Grosbois (Mr.)
FERRARI DATA SOLUTIONS GMBH
Switzerland
EU contribution
€ 452 568
Address
Feldguetliweg 152 152
8706 Meilen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stephen Ferrari (Mr.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 90 000
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carsten Glueck (Mr.)
PHARMALYS LTD
United Kingdom
EU contribution
€ 115 000
Address
Warwick Road Warwick House
WD6 1GS Borehamwood
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Asta Stankeviciene (Ms.)
MAETZEL ANDREAS - MAETZEL CONSULTING
Switzerland
Address
Baarerstrasse 12
6300 Zug
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andreas Maetzel (Prof.)
DSM Nutritional Products Ltd
Switzerland
Address
Wurmisweg 576
4303 Kaiseraugst
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Kriegel (Mr.)
NESTEC SA
Switzerland
Address
Avenue Nestle 55
1800 Vevey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Noel Kearins (Mr.)
ROCHE DIAGNOSTICS (SCHWEIZ) AG
Switzerland
Address
Industriestrasse 7
6343 Rotkreuz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Françoise-Marie Hannes (Ms.)
GUT BENNO PHILIPP ALOIS
Switzerland
EU contribution
€ 129 000
Address
Rigiweg 9
8810 Horgen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Benno Gut (Mr.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 446 154,60
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kurt Kamber (Dr.)