CORDIS
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CORDIS

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VitaminD3-Omega3-Home Exercise- HeALTHy Ageing and Longevity Trial

Project information

Grant agreement ID: 278588

Status

Closed project

  • Start date

    1 January 2012

  • End date

    30 June 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 13 067 968,25

  • EU contribution

    € 5 999 548

Coordinated by:

UNIVERSITAT ZURICH

Switzerland

Objective

As the European population is ageing rapidly, the growing number of seniors with age-related chronic diseases poses a challenge on European societies and health care systems. Therapeutic interventions that are effective, affordable and well-tolerated in the prevention of chronic disease are urgently needed and will have an outstanding impact on public health as a whole. Among the most promising interventions that meet these requirements are vitamin D, marine omega-3 fatty acids and physical exercise. However, their individual and combined effects have yet to be confirmed in a clinical trial. The DO-HEALTH will close this knowledge gap in a large 3-year multi-centre clinical trial that will establish long-term efficacy and safety data for the 3 interventions in the prevention of age-related diseases in seniors.
The DO-HEALTH trial will enrol 2152 community-dwelling men and women aged 70 and older, when chronic diseases increase substantially. The randomized-controlled trial will test the individual and the combined benefit of 2000 IU vitamin D/day, 1 g of omega-3 fatty acids/day and a simple home exercise program in an efficient factorial trial design. DO-HEALTH will establish evidence in 5 primary endpoints: the risk of incident non-vertebral fractures; the risk of functional decline; the risk of blood pressure increase; the risk of cognitive decline; and the rate of any infection. Key secondary endpoints include risk of hip fracture, rate of falls, pain in symptomatic knee osteoarthritis, glucose tolerance, gastro-intestinal symptoms, mental and oral health, quality of life, and mortality. Follow-up will be in-person, in 3-monthly intervals (4 clinical visits and 9 phone calls). DO-HEALTH will further assess the comparative effectiveness of the interventions by evaluating reasons why or why not seniors adhere to them, and will assess their cost-benefit in a health economic model based on documented health care utilization and observed incidence of chronic disease.

Coordinator

UNIVERSITAT ZURICH

Address

Ramistrasse 71
8006 ZÜRich

Switzerland

Activity type

Other

EU Contribution

€ 1 479 647,75

Administrative Contact

Heike Bischoff-Ferrari (Prof.)

Participants (23)

FERRARI STEPHEN MARIO

Switzerland

NOVAMEN SAS

France

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 368 950

UNIVERSITATSSPITAL BASEL

Switzerland

EU Contribution

€ 5 726,40

CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE

France

EU Contribution

€ 704 093

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 798 125,08

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG

Germany

EU Contribution

€ 15 416,17

MAX RUBNER INSTITUT BUNDESFORSCHUNGSINSTITUT FUR ERNAEHRUNG UND LEBENSMITTEL

Germany

EU Contribution

€ 67 500

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU Contribution

€ 358 450

UNIVERSIDADE DE COIMBRA

Portugal

EU Contribution

€ 677 031

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 44 318

THE UNIVERSITY OF SHEFFIELD

United Kingdom

EU Contribution

€ 37 568

INTERNATIONAL OSTEOPOROSIS FOUNDATION

Switzerland

EU Contribution

€ 30 000

ACIES Consulting Group SAS

France

EU Contribution

€ 180 000

FERRARI DATA SOLUTIONS GMBH

Switzerland

EU Contribution

€ 452 568

TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 90 000

PHARMALYS LTD

United Kingdom

EU Contribution

€ 115 000

MAETZEL ANDREAS - MAETZEL CONSULTING

Switzerland

DSM Nutritional Products Ltd

Switzerland

NESTEC SA

Switzerland

ROCHE DIAGNOSTICS (SCHWEIZ) AG

Switzerland

GUT BENNO PHILIPP ALOIS

Switzerland

EU Contribution

€ 129 000

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 446 154,60

Project information

Grant agreement ID: 278588

Status

Closed project

  • Start date

    1 January 2012

  • End date

    30 June 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 13 067 968,25

  • EU contribution

    € 5 999 548

Coordinated by:

UNIVERSITAT ZURICH

Switzerland