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Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications

Objective

Marine microorganisms form an almost untapped resource of biotechnological potential. However, its use is hindered by the low success rate of isolation of novel microorganisms and often by poor growth efficiency. Hence, the vast majority of marine microorganisms has not been cultivated and is often considered as ‘unculturable’. MaCuMBA aims at improving the isolation rate and growth efficiency of marine microorganisms from conventional and extreme habitats, by applying innovative methods, and the use of automated high throughput procedures. The approaches include the co-cultivation of interdependent microorganisms, as well as gradient cultures and other methods mimicking the natural environment, and the exploitation of cell-to-cell communication. Signaling molecules produced by microorganisms may be necessary for stimulating growth of the same or other species, or may prevent their growth. Signaling molecules also represent an interesting and marketable product. MaCuMBA will make use of high throughput platforms such Cocagne, using gel micro-droplet technology, or MicroDish in which many thousands of cultures are grown simultaneously. Various single-cell isolation methods, such as optical tweezers, will aid the isolation of specific target cells. Isolated microorganisms as well as their genomes will be screened for a wide range of bioactive products and other properties of biotechnological interest, such as genetic transformability. Growth efficiency and expression of ‘silent’ genes of selected strains will be increased also by using the clues obtained from genomic information. MaCuMBA is targeted to SMEs and industry and they make a significant part of the consortium, ensuring that the project focuses on the interests of these partners. Moreover, MaCuMBA has adopted a comprehensive and professional exploitation, dissemination, implementation, and education strategy, ensuring that MaCuMBA’s results and products will be directed to end-users and stakeholders.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-KBBE-2012-6-singlestage
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

STICHTING NIOZ, KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE
Address
Landsdiep 4
1797 SZ Den Hoorn Texel
Netherlands
Activity type
Research Organisations
EU contribution
€ 1 349 291
Administrative Contact
Marcel Van Der Linden (Mr.)

Participants (23)

UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 426 436
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Birgitta Van Wijnen (Ms.)
UNIVERSITE DE BRETAGNE OCCIDENTALE
France
EU contribution
€ 765 467
Address
Rue Des Archives 3
29238 Brest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Queffelec (Ms.)
AQUAPHARM BIODISCOVERY LIMITED

Participation ended

United Kingdom
Address
Glenfinlas Street
EH3 6AQ Edinburgh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrew Mearns Spragg (Dr.)
CYANO BIOTECH GMBH
Germany
EU contribution
€ 272 268
Address
Magnusstrasse 11
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dan Kramer (Dr.)
MICRODISH BV
Netherlands
EU contribution
€ 398 084
Address
Schipholweg 275
1171 PK Badhoevedorp
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Hessing (Dr.)
POLYMARIS BIOTECHNOLOGY
France
EU contribution
€ 290 341
Address
Pepinieres D'entreprises - Aeropole Centre
29600 Morlaix
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bertrand Thollas (Dr.)
ECOAST
Belgium
EU contribution
€ 150 000
Address
Esplanade 1
8400 Oostende
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Vanagt (Mr.)
AQUA TT UETP COMPANY LIMITED BY GUARANTEE
Ireland
EU contribution
€ 405 000
Address
Pleasants Street Olympic House
8 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marieke Reuver (Ms.)
MATIS OHF
Iceland
EU contribution
€ 300 442
Address
Vinlandsleid 12
113 Reykjavik
Activity type
Research Organisations
Administrative Contact
Viggo Thor Marteinsson (Dr.)
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
EU contribution
€ 420 219
Address
Avenida De La Universidad S-n
03202 Elche
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rafael Gandia Balaguer (Mr.)
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 441 826
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
Administrative Contact
David O'connell (Dr.)
THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 396 977
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hedges (Dr.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 500 559
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jette Jensen (Ms.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 301 740
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margherita Pasetti (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 499 979
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Emmanuelle Malesys (Ms.)
HERIOT-WATT UNIVERSITY
United Kingdom
EU contribution
€ 434 516
Address
Riccarton
EH14 4AS Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Olszewska-Day (Dr.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 299 592
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wolfgang R. Hess (Prof.)
PHARMAMAR, S.A.
Spain
EU contribution
€ 281 016
Address
Avda. De Los Reyes , Poligono Industrial La Mina 1
28770 Colmenar Viejo (Madrid)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guillermo Jimenez (Mr.)
LEIBNIZ-INSTITUT DSMZ-DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN GMBH
Germany
EU contribution
€ 301 200
Address
Inhoffenstrasse 7B
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Birgit Gerstel (Prof.)
BIOALVO S.A.

Participation ended

Portugal
Address
Edifício Icat, Campus Da Fcul, Campo Grande
1749-016 Lisbon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patricia Calado (Dr.)
Ribocon GmbH
Germany
EU contribution
€ 143 700
Address
Fahrenheitstrasse 1
28359 Bremen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jörg Peplies (Dr.)
FERMENTALG SA
France
EU contribution
€ 300 112
Address
Rue Riviere 4
33500 Libourne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Michalet (Mr.)
SEALIFE PHARMA GMBH
Austria
EU contribution
€ 321 183
Address
Technopark 1 Geb B Eg
3430 Tulln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Pretsch (Dr.)