Objective Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothesis-driven reductionist approaches to understand the molecular basis of ageing. Whereas molecular and cellular damage is thought to be a cause of ageing and age-related pathologies, little is known about the molecular events that underlie ageing or determine longevity. A large number of progeroid syndromes that are characterized by an early onset of age-related pathology are linked to inborn defects in genome maintenance thus pointing towards damage in (nuclear) DNA as a major culprit of ageing and age-related pathology. DNA damage fuelled by intrinsic andenvironmental sources of genotoxic insult and by errors of genome maintenance mechanisms invariably accumulates with advancing age. The outcome of DNA damage is diverse and generally adverse: DNA lesions may physically obstruct essential processes including DNA replication and transcription. In addition, DNA damage activates checkpoint responses that lead to a reduction in cell proliferation potential (cellular senescence) or to an increase in cell death. As a result, depending on the type and severity of DNA injuries and the cellular response to DNA damage, these cellular mechanisms impair organ maintenance and function during ageing. The CodAge ITN proposes an integrated approach in studying the role of Chronic DNA damage in Ageing and age-related pathology. Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2012-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator UNIVERSITAT ZU KOLN EU contribution € 792 370,78 Address ALBERTUS MAGNUS PLATZ 50931 Koln Germany See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Heike Brucherseifer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all IDRYMA TECHNOLOGIAS KAI EREVNAS Greece EU contribution € 910 022,52 Address N PLASTIRA STR 100 70013 Irakleio See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Administrative Contact Zinovia Papatheodorou (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution € 570 113,28 Address KINGS GATE NE1 7RU Newcastle Upon Tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Aleona Blinova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Italy EU contribution € 240 837,96 Address VIA ADAMELLO 16 20139 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Carlo Raimondi Cominesi (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LEIBNIZ-INSTITUT FUR ALTERNSFORSCHUNG - FRITZ-LIPMANN-INSTITUT EV (FLI) LEIBNIZ INSTITUTE ON AGING - FRITZ LIPMANN INSTITUTE EV (FLI) Germany EU contribution € 222 068,88 Address BEUTENBERGSTRASSE 11 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Wilfried Briest (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 246 086,94 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Joachim Lingner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MOSAIQUES DIAGNOSTICS GMBH Germany EU contribution € 222 068,88 Address ROTENBURGER STRASSE 20 30659 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Harald Mischak (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS Greece EU contribution € 222 068,88 Address ALEXANDER FLEMING STREET 34 16672 Vari See on map Region Αττική Aττική Ανατολική Αττική Administrative Contact Maria Denis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ATLAS BIOLABS GMBH Germany EU contribution € 222 068,88 Address KERPENER STRASSE 61-69 50937 KOLN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Karsten Heidtke (Dr.) Links Contact the organisation Opens in new window Total cost No data