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Ancient Pathogen Genomics of Re-Emerging Infectious Disease

Obiettivo

Here we propose a first step toward a direct reconstruction of the evolutionary history of human infectious disease agents by obtaining genome wide data of historic pathogens. Through an extensive screening of skeletal collections from well-characterized catastrophe, or emergency, mass burials we plan to detect and sequence pathogen DNA from various historic pandemics spanning at least 2,500 years using a general purpose molecular capture method that will screen for hundreds of pathogens in a single assay. Subsequent experiments will attempt to reconstruct full genomes from all pathogenic species identified. The molecular fossil record of human pathogens will provide insights into host adaptation and evolutionary rates of infectious disease. In addition, human genomic regions relating to disease susceptibility and immunity will be characterized in the skeletal material in order to observe the direct effect that pathogens have made on the genetic makeup of human populations over time. The results of this project will allow a multidisciplinary interpretation of historical pandemics that have influenced the course of human history. It will provide priceless information for the field of history, evolutionary biology, anthropology as well as medicine and will have direct consequences on how we manage emerging and re-emerging infectious disease in the future.

Invito a presentare proposte

ERC-2012-StG_20111109
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Meccanismo di finanziamento

ERC-SG - ERC Starting Grant

Istituzione ospitante

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Indirizzo
Hofgartenstrasse 8
80539 Munchen
Germania
Tipo di attività
Research Organisations
Contributo UE
€ 594 642
Contatto amministrativo
Beate Kerpen (Ms.)
Ricercatore principale
Johannes Krause (Prof.)

Beneficiari (2)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germania
Contributo UE
€ 594 642
Indirizzo
Hofgartenstrasse 8
80539 Munchen
Tipo di attività
Research Organisations
Contatto amministrativo
Beate Kerpen (Ms.)
Ricercatore principale
Johannes Krause (Prof.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN

Partecipazione conclusa

Germania
Contributo UE
€ 879 918
Indirizzo
Geschwister-scholl-platz
72074 Tuebingen
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Elisabeth Baier (Mrs.)