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User-driven Development of Statistical Methods for Experimental Planning, Data Gathering, and Integrative Analysis of Next Generation Sequencing, Proteomics and Metabolomics data

Objective

Users of NGS technologies, producing large and numerous distinct types of omics data, demands statistical methods to combat data and knowledge fragmentation and inappropriate procedures for data analysis. Yet, the current a gap between the available tools for analysis of a single omics data-type versus the requirement of biomedical scientists to understand the integrated results derived from several omics data-types, threatens to further increase due to the accelerated capacity of data production.
STATegra will therefore improve and develop new statistical methods enabling accurate collection and integration of –omics data while providing user-friendly packaging of STATegra tools targeting biomedical scientists. To close the gap between the present sub-optimal utilization of –omics data and the power of statistics, STATegra develops statistical methods targeting efficient experimental design, data gathering, missing data, noisy data, current knowledge, meta-analysis and integrative data analysis.
Importantly, STATegra facilitates understanding and use of –omics data by forcing abstract concepts including knowledge, design, dirty data, visualization, causality and integration to be embedded in a real yet prototypical biomedical context. STATegra is positioned to ensure that the collective output of the statistical STATegra methods is relevant and subject to “statistical and experimental” validation and iteration. STATegra mimics a user-driven IT development strategy, by involving real biomedical users as beta-testers.
To deliver beyond current exploratory tools, our consortium accumulates the necessary strong statistical, technological, and molecular expertise. The strong lead by research intensive SMEs, with proven track-record in software deployment, translates STATegra to a wide existing community base. STATegra accelerates the production of relevant statistical tools impacting a broad community of biomedical scientists in research, industry, and healthcare.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Coordinator

FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE
Address
Calle Eduardo Primo Yufera 3
46012 Valencia
Spain
Activity type
Research Organisations
EU contribution
€ 575 819,10
Administrative Contact
Eugenia Flores (Ms.)

Participants (10)

QIAGEN AARHUS AS
Denmark
EU contribution
€ 956 912
Address
Silkeborgvej 2
8000 Aarhus
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Knudsen (Mr.)
BIOMAX INFORMATICS AG
Germany
EU contribution
€ 425 500
Address
Robert Koch Strasse 2
82152 Planegg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dieter Maier (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 680 332,08
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Miles Davies (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 689 440,85
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 528 874,69
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
Administrative Contact
Zinovia Papatheodorou (Mrs.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 583 026,79
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Activity type
Research Organisations
Administrative Contact
Laia Lagunas (Ms.)
UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 580 302,94
Address
Spui 21
1012WX Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan-Willem Bleeker (Dr.)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 443 676,10
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (Mr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 298 122
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Axel Imhof (Prof.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 236 567,98
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ali Mortazavi (Prof.)