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A Portable bihormonal Closed Loop for Diabetes

Objective

The aim of PCDIAB is to build and evaluate a bihormonal (insulin and glucagon) artificial pancreas (AP) with automated closed loop glycaemic control for insulin treated patients with diabetes. This will be a breakthrough in diabetes management. We will miniaturize our current prototype consisting of well-established continuous glucose monitors, an insulin pump and a glucagonpump. The housing will be redesigned with dedicated miniature motors and the software will be embedded. The algorithm will be improved and a continuous glucose sensor (CGM) per-formance alert will be developed. In parallel, glucagon pharmacology will be investigated and a stable liquid glu-cagon analogue will be developed. Furthermore, administration of insulin and glucagon together with continuous glucose monitoring at the same subcutaneous site will be investigated, to enable even further miniaturization in the future.
Deliverables include description of system integration of the bihormonal AP system and of an online detection of continuous glucose monitor performance. In a multinational controlled trial the bihormonal AP will be compared with standard intensive insulin therapy in daily life.
Impact of the project includes simplified diabetes care, improved quality of life for patients with diabetes, dimin-ished occurrence of diabetes related complications and diminished health costs in the long run. Also, the project will strengthen competitiveness of European industry across a complete value chain involving large, mid-sized and small companies, enabling Europe to lead progress in AP systems. Finally, the project will put European research and clinical organizations in leading positions with an increased number of high-skilled jobs in the medical device industry.
Dissemination and exploitation comprises a website, a conference, patents and scientific publications. The bihormonal closed loop system and the glucagon analogue can be developed into a product and brought to the market.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rebecca Massonet (Ms.)
EU contribution
€ 1 203 772,20

Participants (6)

MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 632 360
Address
Auenbruggerplatz 2
8036 Graz

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Waltraud Schulter (Ms.)
INREDA DIABETIC BV
Netherlands
EU contribution
€ 908 400
Address
Diepenheimseweg 19
7471LW Goor

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Wim Smit (Mr.)
NOVO NORDISK A/S

Participation ended

Denmark
EU contribution
€ 6 646,80
Address
Novo Alle 1
2880 Bagsvaerd

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Julie Rehoff Hansen (Ms.)
Profil Institut fur Stoffwechselforschung GmbH
Germany
EU contribution
€ 771 390
Address
Hellersbergstrasse 9
41460 Neuss

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Herrmann Ekkehard (Mr.)
FULL YAZILIM MUHENDISLIK REKLAM TANITIM TURIZM ORGANIZASYON SANAYI TICARET LIMITED SIRKETI
Turkey
EU contribution
€ 411 060
Address
Caglayan Mahallesi 2011 Sokak 5 B
070230 Muratpasa Antalya

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ulaş Utku Tosun (Mr.)
UNIVERSITEIT TWENTE
Netherlands
EU contribution
€ 401 655
Address
Drienerlolaan 5
7522 NB Enschede

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda De Kleijn - Collije (Ms.)