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European Consortium for High-Throughput Research in Rare Kidney Diseases

European Consortium for High-Throughput Research in Rare Kidney Diseases

Objective

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (‘functiomics’) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITATSKLINIKUM HEIDELBERG

Address

Im Neuenheimer Feld 672
69120 Heidelberg

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 973 178,18

Administrative Contact

Thorsten Brietz (Mr.)

Participants (28)

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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 1 845 713

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 584 788

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

EU Contribution

€ 650 001

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 474 910

University of Michigan/Autophagy Journal

United States

EU Contribution

€ 418 198

HACETTEPE UNIVERSITESI

Turkey

EU Contribution

€ 375 000

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 249 517

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 521 691

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 249 883

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 374 156

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 240 000

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU Contribution

€ 149 592

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

EU Contribution

€ 149 640

LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT

Germany

EU Contribution

€ 150 000

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 49 998

OULUN YLIOPISTO

Finland

EU Contribution

€ 234 900

Genomatix Software GmbH

Germany

EU Contribution

€ 957 000

METABOMETRIX LTD

United Kingdom

EU Contribution

€ 487 000

MULTIPLICOM NV

Belgium

EU Contribution

€ 351 600

PHILOGEN SPA

Italy

EU Contribution

€ 149 960

PHILOCHEM AG

Switzerland

EU Contribution

€ 440 000

HUMMINGBIRD DIAGNOSTICS GMBH

Germany

EU Contribution

€ 390 000

MOSAIQUES DIAGNOSTICS GMBH

Germany

EU Contribution

€ 345 000

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

EU Contribution

€ 214 407,82

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Germany

EU Contribution

€ 2 653,50

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 516 052

ACQUIFER AG

Germany

EU Contribution

€ 280 000,50

CMAST

Belgium

EU Contribution

€ 169 728

Project information

Grant agreement ID: 305608

Status

Closed project

  • Start date

    1 October 2012

  • End date

    30 September 2017

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 854 880,57

  • EU contribution

    € 11 994 567

Coordinated by:

UNIVERSITATSKLINIKUM HEIDELBERG

Germany