Skip to main content

European Consortium for High-Throughput Research in Rare Kidney Diseases

Objective

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (‘functiomics’) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents.

Field of science

  • /humanities/philosophy, ethics and religion/philosophy/metaphysics/ontology
  • /medical and health sciences/clinical medicine/nephrology/kidney diseases

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITATSKLINIKUM HEIDELBERG
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 973 178,18
Administrative Contact
Thorsten Brietz (Mr.)

Participants (28)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 845 713
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Nicolas Jeanjean (Mr.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 584 788
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Olivier Devuyst (Prof.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 650 001
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 474 910
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joost Warsanis (Mr.)
UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN
United States
EU contribution
€ 418 198
Address
South Street 3003 1068
46109 1274 Ann Arbor
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christine Koch (Ms.)
HACETTEPE UNIVERSITESI
Turkey
EU contribution
€ 375 000
Address
Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi
06800 Cankaya Ankara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fatih Ozaltin (Prof.)
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 249 517
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elodie Mahieu-Wedande (Mrs.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 521 691
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 249 883
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katherine Boylan (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 374 156
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Borg-Carbott Greta (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 240 000
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Alberto Sereno Alvarez (Prof.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 149 592
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aleona Blinova (Ms.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 149 640
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Alix Pillot (Ms.)
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT
Germany
EU contribution
€ 150 000
Address
Beutenberg Strasse 11A
07745 Jena
Activity type
Research Organisations
Administrative Contact
Michael Ramm (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 49 998
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah Malevé (Ms.)
OULUN YLIOPISTO
Finland
EU contribution
€ 234 900
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arto Eljander (Mr.)
Genomatix Software GmbH
Germany
EU contribution
€ 957 000
Address
Bayerstrasse 85A
80335 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Korbinian Grote (Dr.)
METABOMETRIX LTD
United Kingdom
EU contribution
€ 487 000
Address
Prince Consort Road
SW7 2BP London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Lindon (Prof.)
MULTIPLICOM NV
Belgium
EU contribution
€ 351 600
Address
Galileilaan 18
2845 Niel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Luc Lammens (Mr.)
PHILOGEN SPA
Italy
EU contribution
€ 149 960
Address
Piazza La Lizza 7
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Chiara Falciani (Dr.)
PHILOCHEM AG
Switzerland
EU contribution
€ 440 000
Address
Libernstrasse 3
8112 Otelfingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sarah Wulhfard (Dr.)
HUMMINGBIRD DIAGNOSTICS GMBH
Germany
EU contribution
€ 390 000
Address
Im Neuenheimer Feld 583
69120 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Markus Beier (Dr.)
MOSAIQUES DIAGNOSTICS GMBH
Germany
EU contribution
€ 345 000
Address
Rotenburger Strasse 20
30659 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Zürbig (Dr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 214 407,82
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
KARLSRUHER INSTITUT FUER TECHNOLOGIE

Participation ended

Germany
EU contribution
€ 2 653,50
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Natascha Kindsvogel (Ms.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 516 052
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
André Brändli (Prof.)
ACQUIFER AG
Germany
EU contribution
€ 280 000,50
Address
Freiburger Strasse 1-3
75179 Pforzheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ralf Mulflur
CMAST
Belgium
EU contribution
€ 169 728
Address
Georges Van Dammeplein 57
9140 Temse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karin Van Den Eeden (Mrs.)