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Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial

Objective

Pregnant women are very susceptible to malaria infection and Malaria in Pregnancy (MiP) is a major cause of maternal anaemia and low birth weight (LBW) that leads to infant mortality, poor growth and development. In low transmission areas, malaria can become severe, resulting in maternal and foetal death. In sub-Saharan Africa (SSA) MiP is responsible for 8–14% of LBW, 3–8% of infant deaths, higher risk of post-partum haemorrhage and >10,000 maternal deaths/year. Prevention like, bed nets and intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp/SP), is cheap and cost-effective, but coverage achieved by these interventions is low. Therefore, we propose Community Health Workers (CHW) to implement scheduled intermittent screening at community level with RDT of pregnant women and if positive treat with anti-malarials (SST). In addition CHWs will encourage pregnant women to attend antenatal clinics (ANC) for other pregnancy-targeted interventions and IPTp/SP, thereby improving its coverage. This approach combines existing IPTp/SP with SST at village level as an extension of Home based management of malaria (HMM). This low cost (based on existing practice) and simple (diagnosis by RDTs) intervention improves maternal and newborn health and capitalise on an already existing intervention (HMM). The aim of this proposal is to determine the added value (as compared to IPTp/SP alone implemented in health facilities) of community SST of pregnant women implemented through the CHW involved in HMM. Objectives are: 1) Identify bottlenecks for implementation by CHW involved in HMM of SST; 2) determine impact of introducing SST in pregnancy on quality of HMM; 3) determine the impact of SST on ANC attendance and IPTp/SP coverage; 4) determine the impact of SST on LBW, anaemia and placenta malaria; 5) estimate cost-effectiveness of SST as compared to IPTp/SP alone and 6) formulate recommendations for possible implementation of the intervention.

Field of science

  • /medical and health sciences/health sciences/infectious disease/malaria
  • /social sciences/sociology/demography/fertility
  • /social sciences/sociology/demography/mortality

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 54 039,69
Administrative Contact
Gulseren Yalvac (Mrs.)

Participants (7)

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
EU contribution
€ 260 360,40
Address
Nationalestraat 155
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Mostmans (Ms.)
CENTRE MURAZ
Burkina Faso
EU contribution
€ 694 719
Address
Avenue Mamadou Konate
NA Bobo-dioulasso
Activity type
Research Organisations
Administrative Contact
Ida Ouédraogo (Ms.)
Ministere de la sante
Benin
EU contribution
€ 566 998
Address
N/a
06 BP 3029 Cotonou
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Alain Nahum (Dr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 619 592
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Dembo Kanteh (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 199 958
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Tatjana Palalic (Ms.)
WORLD HEALTH ORGANIZATION
Switzerland
EU contribution
€ 186 775,20
Address
Avenue Appia 20
1211 Geneve
Activity type
Research Organisations
Administrative Contact
Melba Gomes (Dr.)
HET KONINKLIJK INSTITUUT VOOR DE TROPEN

Participation ended

Netherlands
EU contribution
€ 414 775,71
Address
Mauritskade 63
1092 AD Amsterdam
Activity type
Research Organisations
Administrative Contact
Hendricus Schallig (Dr.)