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The Sugar Code: from (bio)chemical concept to clinics

The Sugar Code: from (bio)chemical concept to clinics

Objective

Coding of biochemical information is commonly described to be based solely on nucleotides and amino acids, whereas carbohydrates, the most abundant type of molecule in Nature, appear sidelined in this respect. That carbohydrates, as part of cellular glycoconjugates, have exceptional talents for building biochemical signals is an emerging insight, at the heart of the concept of the Sugar Code. Intuitively, emergence of recognition partners for information transfer is expected, and this is the case. Thus, coding of bioinformation in glycans and information transfer via lectins is key to a wealth of medically relevant processes, e.g. infection, immune regulation and malignancy, now awaiting its full exploitation pharmaceutically. To do so, training in this exceptionally interdisciplinary field needs to be provided. With this aim, scientific and country/gender issues are strategically combined in this network. Its composition assures a continuous chain of research expertise, from computational and synthetic chemistry to state of the art biophysical chemistry and structural biology, then to biochemistry, molecular cell biology and pharmaceutical/biomedical sciences, generating innovative clinical approaches. Notably, academia is linked with industry, bringing in the essence of business acumen into the training programme. This activity and the research deliberately planned as interdisciplinary projects ensure an optimal training for young researchers in a dynamically developing area of conspicuous biopharmaceutical potential. Equally important, it lays the foundation to inspire novel strategies for the design of potent and selective inhibitors against lectins and the development of lectins (or suitably engineered variant(s)) as therapeuticals. As a boon for the success of the network, cooperations between several partners have already proven successful, especially increasing the core in Madrid and partners in Dublin, Munich and Prague.
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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 047 070,94

Administrative Contact

Ana Maria De La Fuente (Ms.)

Participants (10)

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FUNDACION UNIVERSITARIA SAN PABLO-CEU

Spain

EU Contribution

€ 96 620,96

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 435 025,91

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 235 268,88

UNIVERSIDADE DO MINHO

Portugal

EU Contribution

€ 219 681

UNIVERZITA KARLOVA

Czechia

EU Contribution

€ 218 408,52

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 235 268,88

ISOSEP AKTIEBOLAG

Sweden

INSTITUTE OF APPLIED BIOTECHNOLOGIES AS

Czechia

EU Contribution

€ 158 849,91

TOSCANA BIOMARKERS S.R.L

Italy

EU Contribution

€ 187 062,70

ROCHE DIAGNOSTICS GMBH

Germany

EU Contribution

€ 172 200,60

Project information

Grant agreement ID: 317297

Status

Closed project

  • Start date

    1 November 2012

  • End date

    31 October 2016

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 3 005 458,30

  • EU contribution

    € 3 005 458,30

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain