Objectif Current theories of declarative memory suggest that it is supported by two complementary memory systems: the medial temporal lobe (MTL) which specializes in rapid acquisition of novel associations and the neocortex, which slowly learns through environmental regularities. Gilboa et al. recently reported an extraordinary phenomenon of rapid acquisition of novel arbitrary associations by adults with severe anterograde amnesia due to extensive MTL lesions. These data challenge the accepted view of dual declarative memory systems and offer a radically different mechanism for directly acquiring semantics without enlisting the hippocampus: the Fast Mapping. Fast Mapping refers to a process that supports vocabulary acquisition among children who do not have a mature hippocampus. They actively infer the meaning of novel words by generating hypotheses based on contextual cues or on the way the words are used in a sentence.By using a multidisciplinary approach, this project aims at highlighting the neural substrates and the cognitive mechanisms underlying this type of learning.First, we will explore the neural basis of FM by a clinical approach. We will contrast the performance of patients whose pathology primarily involves the Anterior Temporal Lobe (Semantic Dementia) with that of patients with more pronounced Medial Temporal Lobe pathology (Alzheimer’s disease).In a second experiment we will use Transcranial Magnetic Stimulation in order to highlight the brain regions that are involved in the FM learning.Experiments 3 and 4 aim at investigating the neurocognitive mechanisms underlying FM. Using a Bayesian framework, we will try to demonstrate how knowledge and inference are used in combination with repeated exposures to guide people in learning new words. We will also use MEG to highlight the patterns’ changes of neocortical activity when participant learn through FM.Finally, we will develop new tools for memory rehabilitation based on the FM acquisition. Champ scientifique natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicinepathology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2011-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2011-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Contribution de l’UE € 244 670,40 Adresse RUE DE TOLBIAC 101 75654 Paris France Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Isabelle Verdier (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée