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Stem-cell based therapy for kidney repair

Objective

Chronic kidney disease (CKD) affects 8% of the European population and ultimately results in renal failure due to progressive fibrosis. CDK carries a high mortality risk and the number of affected people rises, increasing the demand on renal replacement therapies while the number of available donor organs stays stable.

The STELLAR consortium proposes to develop an alternative to renal replacement therapy, based on the repair capacity of newly discovered kidney mesenchymal stromal cells (kMSCs). By injecting kMSC into affected kidneys, we expect to stop kidney fibrosis and induce tissue repair, ultimately leading to the restoration of normal kidney function.

The STELLAR consortium will
• develop protocols for up scalable, high quality isolation of kMSCs and precisely characterize kMSC function in comparison to other MSCs.
• test kMSCs in several murine renal disease models, to study their effects on fibrosis and tissue repair.
• discover mechanisms of kidney repair.
• invest in developing the technology necessary for up scaled isolation and quality control.

The STELLAR consortium combines Australian experts on kMSC isolation and characterisation with European experts on renal failure and compounds the state-of-the-art knowledge, facilities and experience needed to develop and validate this novel form of renal therapy. The inclusion of experienced SMEs, with great technical and scientific know-how about assay and protocol development, further strengthens the consortium and will ensure not only the inclusion of new technology, but also a quick translation from bench to clinical application.

In conclusion, the STELLAR consortium is capable of developing and pre clinical validation of this new cellular therapy for CDK, based on a new understanding of stromal cells and fibroblast function, while also providing the technology required for rapid, large scale application of the therapy after clinical validation.

Field of science

  • /medical and health sciences/clinical medicine/nephrology/kidney diseases

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 327 941
Administrative Contact
A.J. Rabelink (Prof.)

Participants (15)

THE UNIVERSITY OF QUEENSLAND
Australia
Address
St Lucia
4072 Brisbane
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ian Harris (Mr.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 850 960
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 402 500
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enrico Maggi (Prof.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 74 159,78
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
THE ANTIBODY LAB GMBH
Austria
EU contribution
€ 616 814,50
Address
Divischgasse 4
1210 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Renate Berger-Mostler
KUROS BIOSCIENCES BV
Netherlands
EU contribution
€ 1 012 157,60
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Joost De Bruijn (Prof.)
MILTENYI BIOTEC GMBH
Germany
EU contribution
€ 413 000
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sabrina Schmitz (Ms.)
UNIVERSITEIT TWENTE

Participation ended

Netherlands
EU contribution
€ 334 259,35
Address
Drienerlolaan 5
7522 NB Enschede
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ferdinand Damhuis (Mr.)
NIERSTICHTING NEDERLAND
Netherlands
Address
Groot Hertoginnelaan 34
1405 EE Bussum
Activity type
Other
Administrative Contact
Jasper Boomker (Dr.)
THE AUSTRALIAN KIDNEY FOUNDATION - KIDNEY HEALTH AUSTRALIA
Australia
Address
York Street - Ground Floor 100
3205 South Melbourne
Activity type
Other
Administrative Contact
Joanna Stoic (Ms.)
AZIENDA OSPEDALIERA PAPA GIOVANNI XXIII
Italy
EU contribution
€ 104 400
Address
Piazza Oms 1
24127 Bergamo
Activity type
Other
Administrative Contact
Mara Magri (Dr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 437 140,62
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
MURDOCH CHILDRENS RESEARCH INSTITUTE
Australia
Address
Flemington Road Rch
3052 Parkville
Activity type
Research Organisations
Administrative Contact
Nicole Donker (Dr.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 424 717,15
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrej Borejko (Mr.)
SCINUS HOLDING BV
Netherlands
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frank-Jan Van Der Velden (Mr.)