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Beyond the Genome; training the next generation of ophthalmic researchers

Objective

Eye research has often blazed a trail for other disciplines to follow, giving a lead in neuroscience, genetics, the development of gene- and stem-cell therapies and other important areas of medical research. In recent years, geneticists have made many remarkable discoveries of relevance both to normal human vision and the development of inherited retinal pathology. However the genes and mutations identified account for only a proportion of cases of inherited retinal degeneration, and recent discoveries hint at new classes of mutations which are either largely undetected or the significance of which is missed by conventional genetics. In addition, for those genes implicated there often remains a black box between mutations and disease; how do defects in a given protein manifest symptoms in the eye and what underlies the huge variation in symptoms, severity and response to treatment? The objectives of EyeTN are twofold; to address these knowledge gaps through cutting edge research using novel techniques, including transcriptomics analyses, whole genome and single target RNAi, the development of animal and cell-based disease models, stem cell biology, bioinformatics and hands on experience of pharmaceutical research with direct translational targets; and to give the next generation of European ophthalmic researchers unparalleled opportunities to train with a consortium of the best inherited blindness research labs in the world. The Network spans academic, healthcare and commercial research sectors and is already well established with many existing collaborations. All fellows will carry out one or more components of their research and training in a commercial environment and attend a workshop on translating ideas and discoveries into commercially viable Bioscience produces and therapies, fostering an entrepreneurial mindset and ensuring that we train a pool of researchers who are able to communicate effectively with both academic and commercial bioscience colleagues.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/basic medicine/pathology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/clinical medicine/ophthalmology
  • /natural sciences/biological sciences/neurobiology
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

FP7-PEOPLE-2012-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

UNIVERSITY OF LEEDS
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 981 389,08
Administrative Contact
Benjamin Williams (Mr.)

Participants (6)

UNIVERSITEIT GENT
Belgium
EU contribution
€ 272 026,20
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Mrs.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 516 977,84
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
FONDAZIONE TELETHON
Italy
EU contribution
€ 282 524,16
Address
Via Varese 16/B
00185 Roma
Activity type
Research Organisations
Administrative Contact
Irene Mearelli (Mrs.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 487 392,70
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bernd Wissinger (Prof.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 297 634,86
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
William Lepetit (Mr.)
AVACTA LIFE SCIENCES LIMITED
United Kingdom
EU contribution
€ 252 852,16
Address
Street 5 Unit 651 Thorp Arch Estate
LS23 7FZ Wetherby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Ko Ferrigno (Dr.)