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The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe

Objective

The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an “Early-Life Exposome” approach.

HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (>300,000 subjects) and registers, to estimate health impacts at the large European scale.

HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.

Field of science

  • /social sciences/sociology/demography/fertility
  • /medical and health sciences/basic medicine/immunology

Call for proposal

FP7-ENV-2012-two-stage
See other projects for this call

Funding Scheme

CP - Collaborative project (generic)

Coordinator

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Address
C Rossello 132 Planta 05
08036 Barcelona
Spain
Activity type
Research Organisations
Administrative Contact
Diana Van Gent (Dr.)

Participants (13)

FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Participation ended

Spain
EU contribution
€ 2 266 689,85
Address
Calle Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Diana Van Gent (Dr.)
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 2 025 814,50
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
Administrative Contact
Cahtrine Thomsen (Dr.)
PANEPISTIMIO KRITIS
Greece
EU contribution
€ 402 622
Address
University Campus Gallos
74100 Rethimno
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eleni Karkanaki (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 677 604
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Evelyne Bertino (Ms.)
BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 452 948,15
Address
Duckworth Lane
BD9 6RJ Bradford
Activity type
Research Organisations
Administrative Contact
John French (Mr.)
VYTAUTO DIDZIOJO UNIVERSITETAS
Lithuania
EU contribution
€ 342 144
Address
K Donelaicio G 58
44248 Kaunas
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dangirute Radzeviciene (Mrs.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 772 367,90
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 819 492,60
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Xavier Estivill (Dr.)
VEILIGHEIDS- EN GEZONDHEIDSREGIO GELDERLAND-MIDDEN
Netherlands
EU contribution
€ 148 440
Address
Eusebiusbuitensingel 43
6802 EJ Arnhem
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Jeroen Smit (Mr.)
HYLOBATES CONSULTING SRL
Italy
EU contribution
€ 37 312
Address
Via Dei Monfortani 57 B
00100 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Francesca Bucchini (Mrs.)
SENSING & CONTROL SYSTEMS SL
Spain
EU contribution
€ 63 600
Address
Avda Barcelona 105 Edificio Ig-nova Despacho 8
08700 Igualada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alberto Fernandez (Mr.)
INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
EU contribution
€ 163 710
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations
Administrative Contact
Lydia Boutigny (Mrs.)
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
EU contribution
€ 451 194
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Cacheiro