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The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe

The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe

Objective

The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an “Early-Life Exposome” approach.

HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (>300,000 subjects) and registers, to estimate health impacts at the large European scale.

HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.

Coordinator

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Address

C Rossello 132 Planta 05
08036 Barcelona

Spain

Activity type

Research Organisations

Administrative Contact

Diana Van Gent (Dr.)

Participants (13)

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FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Spain

EU Contribution

€ 2 266 689,85

FOLKEHELSEINSTITUTTET

Norway

EU Contribution

€ 2 025 814,50

PANEPISTIMIO KRITIS

Greece

EU Contribution

€ 402 622

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 677 604

BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST

United Kingdom

EU Contribution

€ 452 948,15

VYTAUTO DIDZIOJO UNIVERSITETAS

Lithuania

EU Contribution

€ 342 144

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 772 367,90

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 819 492,60

VEILIGHEIDS- EN GEZONDHEIDSREGIO GELDERLAND-MIDDEN

Netherlands

EU Contribution

€ 148 440

HYLOBATES CONSULTING S.R.L.

Italy

EU Contribution

€ 37 312

SENSING & CONTROL SYSTEMS SL

Spain

EU Contribution

€ 63 600

INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS

France

EU Contribution

€ 163 710

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

EU Contribution

€ 451 194

Project information

Grant agreement ID: 308333

Status

Closed project

  • Start date

    1 January 2013

  • End date

    31 December 2017

Funded under:

FP7-ENVIRONMENT

  • Overall budget:

    € 11 292 724,89

  • EU contribution

    € 8 623 939

Coordinated by:

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Spain