Circuit mechanics of emotions in the limbic system

Ziel

Numerous studies established the role of the limbic system in fear and reward: it integrates sensory information, encodes emotional states and instructs other brain centers to regulate physiology and behavior. The limbic system, however, consists of many distinct and highly interconnected neuronal populations. Resolving how emotions are processed in this network at the level of single neural circuits remains a major challenge.
As entry point into the complexity of emotion circuitry, we propose to study, in exemplary fashion, how fear, as the most basic paradigm for emotions, is processed in key limbic hubs. Genetic manipulation of brain circuitry with electrophysiological methods and Pavlovian conditioning in mice, are powerful tools to explore which and how individual circuits in these hubs control emotional states, and, in turn, how genes and psychoactive drugs modulate circuit activity, emotional states and behavior.
We envision this ERC funded research to uncover general principles of the network organization of both emotions and behaviors. It is our hope that we contribute useful tools and methodological framework for investigating other brain functions in a similar manner.

Wissenschaftliches Gebiet

Finanzierungsplan

ERC-SG - ERC Starting Grant

Gastgebende Einrichtung

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH

EU-Beitrag

€ 1 499 922,00

Adresse

CAMPUS-VIENNA-BIOCENTER 1
1030 Wien
Österreich

Region

Ostösterreich Wien Wien

Aktivitätstyp

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Kontakt Verwaltung

Tanja Winkler (Ms.)

Hauptforscher

Wulf Eckhard Haubensak (Dr.)

Links

Die Organisation kontaktieren Website

Gesamtkosten

Keine Daten

Begünstigte (1)