Objetivo Numerous studies established the role of the limbic system in fear and reward: it integrates sensory information, encodes emotional states and instructs other brain centers to regulate physiology and behavior. The limbic system, however, consists of many distinct and highly interconnected neuronal populations. Resolving how emotions are processed in this network at the level of single neural circuits remains a major challenge.As entry point into the complexity of emotion circuitry, we propose to study, in exemplary fashion, how fear, as the most basic paradigm for emotions, is processed in key limbic hubs. Genetic manipulation of brain circuitry with electrophysiological methods and Pavlovian conditioning in mice, are powerful tools to explore which and how individual circuits in these hubs control emotional states, and, in turn, how genes and psychoactive drugs modulate circuit activity, emotional states and behavior.We envision this ERC funded research to uncover general principles of the network organization of both emotions and behaviors. It is our hope that we contribute useful tools and methodological framework for investigating other brain functions in a similar manner. Ámbito científico medical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinephysiology Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-LS5 - ERC Starting Grant - Neurosciences and neural disorders Convocatoria de propuestas ERC-2012-StG_20111109 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH Aportación de la UE € 1 499 922,00 Dirección CAMPUS-VIENNA-BIOCENTER 1 1030 Wien Austria Ver en el mapa Región Ostösterreich Wien Wien Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Tanja Winkler (Ms.) Investigador principal Wulf Eckhard Haubensak (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH Austria Aportación de la UE € 1 499 922,00 Dirección CAMPUS-VIENNA-BIOCENTER 1 1030 Wien Ver en el mapa Región Ostösterreich Wien Wien Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Tanja Winkler (Ms.) Investigador principal Wulf Eckhard Haubensak (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos