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Systems prediction of Chronic Lung Allograft Dysfunction

Objective

Lung transplantation (LT) is the standard of care for selected patients with chronic respiratory failure. Chronic lung allograft dysfunction (CLAD) (i.e. “Bronchiolitis obliterans syndrome” (BOS) and “Restrictive Allograft Syndrome” (RAS)) represents a major health risk for LT recipients, requiring the use of heavy treatments and possible retransplantation. Observed in almost 50% of patients after 5 years post LT, it is currently impossible to predict the appearance of CLAD before the onset of first symptoms. This project aims to develop the SysCLAD model which will allow to predict, within the 1st year post LT, the recipients at risk of developing CLAD by 3 years post LT. Building upon available data from the cohort of lung transplantation (COLT, recruited since mid-2009), this project will integrate new LT recipients to form the European cohort of lung transplantation (ECOLT). The SysCLAD prediction tool will be based on a mathematical model developed through a system biology approach integrating both clinical and biological data collected from a total of 400 LT recipients. The model will be validated on the first 200 LT recipients (3 years follow-up at project start) and refined using the new set of 200 LT data with 3 years follow-up by 2014. The aim is to identify and validate the signature of CLAD both at the clinical and molecular levels to allow for an early recognition and specific interventions in patients at risk of CLAD. The implementation of the model is expected to significantly improve the cost-effectiveness of post-LT treatments, limit the risk of graft rejection in LT recipients and, ultimately lead to an improved quality of life and a prolonged life expectancy of patients following LT. Finally, the SysCLAD model holds further great promises in the context of other chronic bronchial inflammatory diseases of major incidence such as severe asthma and Chronic Obstructive Pulmonary Disease (COPD) to predict decline in lung function.

Field of science

  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /medical and health sciences/clinical medicine/transplantation
  • /medical and health sciences/health sciences/inflammatory diseases
  • /medical and health sciences/clinical medicine/pneumology/asthma

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Address
Rue Du Bugnon 21
1011 Lausanne
Switzerland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 454 400,50
Administrative Contact
Thuy Oetli (Ms.)

Participants (8)

UNIVERSITE JOSEPH FOURIER GRENOBLE 1
France
EU contribution
€ 522 200
Address
Avenue Centrale, Domaine Universitaire 621
38041 Grenoble
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yann Leroux (Mr.)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France
EU contribution
€ 848 700
Address
Allee De L'ile Gloriette 5
44093 Nantes
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karine Botturi-Cavaillès (Ms.)
NOVADISCOVERY
France
EU contribution
€ 346 970
Address
1 Place Giovanni Da Verrazzano
69009 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
François-Henri Boissel (Mr.)
BIOMAX INFORMATICS AG
Germany
EU contribution
€ 243 765,75
Address
Robert Koch Strasse 2
82152 Planegg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dieter Maier (Dr.)
Eurofins Genomics Europe Sequencing GmbH
Germany
EU contribution
€ 416 616
Address
Jakob Stadler Platz 7
78467 Konstanz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Janet Kenklies (Dr.)
FINOVATIS
France
EU contribution
€ 101 000
Address
Cours Lafayette 68
69003 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Koubi (Dr.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 37 500
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Andreas Ledergerber (Mr.)
HLA ET MEDECINE
France
EU contribution
€ 27 999,75
Address
Avenue Claude Vellefaux 1
75010 Paris
Activity type
Research Organisations
Administrative Contact
Charles Auffray (Dr.)