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Triggerable nanomaterials to modulate cell activity

Objective

The advent of molecular reprogramming and the associated opportunities for personalised and therapeutic medicine requires the development of novel systems for on-demand delivery of reprogramming factors into cells in order to modulate their activity/identity. Such triggerable systems should allow precise control of the timing, duration, magnitude and spatial release of the reprogramming factors. Furthermore, the system should allow this control even in vivo, using non-invasive means. The present project aims at developing triggerable systems able to release efficiently reprogramming factors on demand. The potential of this technology will be tested in two settings: (i) in the reprogramming of somatic cells in vitro, and (ii) in the improvement of hematopoietic stem cell engraftment in vivo, at the bone marrow. The proposed research involves a team formed by engineers, chemists, biologists and is highly multidisciplinary in nature encompassing elements of engineering, chemistry, system biology, stem cell technology and nanomedicine.
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Principal Investigator

Lino Da Silva Ferreira (Dr.)

Host institution

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

Address

Universidade De Coimbra, Largo De Pombal
3004 517 Coimbra

Portugal

Activity type

Research Organisations

EU Contribution

€ 1 699 320

Principal Investigator

Lino Da Silva Ferreira (Dr.)

Administrative Contact

Silvia Sousa (Dr.)

Beneficiaries (1)

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CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

Portugal

EU Contribution

€ 1 699 320

Project information

Grant agreement ID: 307384

Status

Closed project

  • Start date

    1 November 2012

  • End date

    31 October 2017

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 699 320

  • EU contribution

    € 1 699 320

Hosted by:

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

Portugal