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Triggerable nanomaterials to modulate cell activity

Objective

The advent of molecular reprogramming and the associated opportunities for personalised and therapeutic medicine requires the development of novel systems for on-demand delivery of reprogramming factors into cells in order to modulate their activity/identity. Such triggerable systems should allow precise control of the timing, duration, magnitude and spatial release of the reprogramming factors. Furthermore, the system should allow this control even in vivo, using non-invasive means. The present project aims at developing triggerable systems able to release efficiently reprogramming factors on demand. The potential of this technology will be tested in two settings: (i) in the reprogramming of somatic cells in vitro, and (ii) in the improvement of hematopoietic stem cell engraftment in vivo, at the bone marrow. The proposed research involves a team formed by engineers, chemists, biologists and is highly multidisciplinary in nature encompassing elements of engineering, chemistry, system biology, stem cell technology and nanomedicine.

Call for proposal

ERC-2012-StG_20111012
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Host institution

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra
Portugal

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Activity type
Research Organisations
Principal investigator
Lino Da Silva Ferreira (Dr.)
Administrative Contact
Silvia Sousa (Dr.)
EU contribution
€ 1 699 320

Beneficiaries (1)

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Portugal
EU contribution
€ 1 699 320
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra

See on map

Activity type
Research Organisations
Principal investigator
Lino Da Silva Ferreira (Dr.)
Administrative Contact
Silvia Sousa (Dr.)