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Metagenomics in Cardiometabolic Diseases

Objective

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ageing populations and costly treatments. Therapies require novel integrated approaches taking into account CMD natural evolution.

METACARDIS associates European leaders in metagenomics, who have been successful in establishing the structure of the human microbiome as part of the EU FP7 MetaHIT consortium, clinical and fundamental researchers, SME, patients associations and food companies to improve the understanding of pathophysiological mechanisms, prognosis and diagnosis of CMD.

We will use next-generation sequencing technologies and high throughput metabolomic platforms to identify gut microbiota- and metabolomic-derived biomarkers and targets associated with CMD risks. The pathophysiological role of these markers will be tested in both preclinical models and replication cohorts allowing the study of CMD progression in patients collected in three European clinical centres of excellence. Their impact on host gene transcription will be characterised in patients selected for typical features of CMD evolution. Application of computational models and visualisation tools to complex datasets combining clinical information, environmental patterns and gut microbiome, metabolome and transcriptome data is a central integrating component in the research, which will be driven by world leaders in metagenomic and functional genomic data analysis. These studies will identify novel molecular targets, biomarkers and predictors of CMD progression, paving the way for personalized medicine in CMD.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 2 512 788
Administrative Contact
Akouavi Ekoue (Ms.)

Participants (15)

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 2 649 374
Address
Rue De L'universite 147
75338 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Lucie Bourse (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 151 649,80
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 900 050
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kristoffersen Ivan (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 911 396
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Phil Irving (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 699 999
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellen Rydberg (Dr.)
VIB VZW
Belgium
EU contribution
€ 551 590
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 540 000
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Alix Pillot (Ms.)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 715 480
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Stumvoll (Prof.)
DANONE RESEARCH SAS
France
EU contribution
€ 159 400
Address
Route Departementale 128
91767 Palaiseau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicolas Gausseres (Mr.)
CARGILL HAUBOURDIN SAS

Participation ended

France
EU contribution
€ 19 000
Address
Rue Du Marechal Joffre 7
59482 Haubourdin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Douwina Bosscher (Dr.)
CHALMERS TEKNISKA HOEGSKOLA AB
Sweden
EU contribution
€ 550 000
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karin Ryrberg (Ms.)
INSERM TRANSFERT SA
France
EU contribution
€ 496 328
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Catherine Clusel (Dr.)
BIOBYTE SOLUTIONS GMBH
Germany
EU contribution
€ 142 937,20
Address
Bothestrasse 142
69126 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivica Letunic (Dr.)
INST CARDIOMETABOLISME NUTRITION ICAN
France
Address
Boulevard De L'hopital 47-83
75013 Paris
Activity type
Research Organisations
Administrative Contact
Marie-Laure Henrotte (Mrs.)
CARGILL R&D CENTRE EUROPE
Belgium
Address
Havenstraat 84
1800 Vilvoorde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Doreen Vynck (Mrs.)