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Glioma Actively Personalized Vaccine Consortium

Objective

Glioblastoma (GBM) is a rare (2-3 incidences in 100,000) and fatal disease. Each year, approximately 13,000 new cases of GBM are diagnosed in Europe. The 5-year survival rate of this highly aggressive tumor entity under conventional therapy is less than 6%. Currently available therapeutic options neglect the individuality of each patients’ disease and only temporarily influence tumor progression with poor effect on overall survival. Introduction of novel highly innovative personalized approaches would have tremendous impacts for the life course of affected patients without additive toxicities. Active cancer immunotherapy aims to trigger the patients´ immune system, specifically cytotoxic T lymphocytes (CTLs) and T helper cells, to defend the body against the cancerous disease. The Glioma Actively Personalized Vaccine Consortium (GAPVAC) aims to conduct a highly innovative pioneering project with active personalized immunotherapy to improve patient treatment. In a Phase I/II study at the center of this proposal, glioblastoma patients will receive a fully personalized peptide-based vaccine as a result of full-genome sequencing and complete peptidomics analysis of the patient’s tumor. Thus, the latest developments in next-generation sequencing, proteomics, immunology, biomarker research and small-scale GMP peptide manufacturing will be uniquely combined to deliver the next generation of personalized medicine to cancer patients. GAPVAC’s goal is to test safety, feasibility and efficacy (biological and early clinical) of this totally novel, completely personalized approach of immunotherapy. GAPVAC is therefore specifically answering the call HEALTH.2012.1.2-1 Development of technologies with a view to patient group stratification for personalized medicine applications by a 4 years project.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Coordinator

IMMATICS BIOTECHNOLOGIES GMBH
Address
Paul Ehrlich Str 15
72076 Tuebingen
Germany

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mark Bleckmann (Mr.)
EU contribution
€ 1 588 636,06

Participants (12)

UNIVERSITY OF GLASGOW

Participation ended

United Kingdom
EU contribution
€ 1 108,34
Address
University Avenue
G12 8QQ Glasgow

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 246 108
Address
Kongens Vaenge 2
3400 Hillerod

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Per Thor Straten (Prof.)
BIONTECH AG
Germany
EU contribution
€ 1 143 277
Address
Holderlinstrasse 8
55131 Mainz

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jürgen Rössler (Mr.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 908 858,40
Address
Geschwister-scholl-platz
72074 Tuebingen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans Georg Rammensee (Prof.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 231 108
Address
Rue Du General Dufour 24
1211 Geneve

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pierre Yves Dietrich (Prof.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 251 107,20
Address
Im Neuenheimer Feld 672
69120 Heidelberg

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Eisenhauer (Mr.)
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
EU contribution
€ 303 750
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lavan Jack (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 297 108
Address
Albinusdreef 2
2333 ZA Leiden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marlien Vos (Mrs.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 231 108
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Joan Comella (Dr.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 231 108
Address
Highfield
SO17 1BJ Southampton

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yan Qiao (Ms.)
IMMUNOLOGISCHE KREBS-THERAPIE EV
Germany
EU contribution
€ 37 799
Address
Langenbeckstrasse 1
55131 Mainz

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Activity type
Other
Administrative Contact
Cécile Gouttefangeas (Dr.)
BCN PEPTIDES SA
Spain
EU contribution
€ 499 360
Address
Carretera Comarcal C-244 Km 22 Poligon Industrial Els Fogars Sector Ii
08777 Santa Quinti De Mediona

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Berta Ponsati (Dr.)