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Concurrent Tuberculosis and Diabetes Mellitus;
unraveling the causal link, and improving care

Objective

Diabetes (DM) triples the risk of developing tuberculosis (TB). Consequently, the alarming growth of type 2 DM in TB endemic countries and among people originating from TB-endemic countries poses a serious threat to global TB control.
This project addresses the scarce evidence for many of the recently advocated guidelines for care and control of TB and DM, as well as our lack of understanding of the mechanisms underlying the effect of DM on TB susceptibility and treatment outcome.
We will use a comprehensive and integrated approach combining clinical, epidemiological and cutting edge expertise in laboratory sciences, bringing together a multi-disciplinary consortium linking field sites in Romania, Peru, South Africa and Indonesia, with leading laboratories in Germany, United Kingdom and the Netherlands.
We will define the optimal and most cost-effective ways of screening TB patients for DM diabetes, and determine the prevalence of DM among TB patients and of TB in DM patients in the four countries. With regard to treatment, we will determine the level of DM management required during and after TB treatment, the safety and pharmacokinetics of metformin when combined with rifampicin, and the effect of hyperglycemia control on TB treatment outcome. To help establish the cellular basis and immunological pathways underlying the link between DM and TB we will provide new data on: gene expression data of TB patients with and without DM; ex vivo and in vitro Mycobacterium tuberculosis stimulation data of different cell types, including macrophage subsets and adipocytes in the presence of high glucose and insulin; data regarding the role of common and more rare genetic variants in the combined susceptibility to TB and type 2 DM; and relevant functional genomics experiments.
In summary, this project is expected to have significant impact both in improving basic knowledge on the link between TB and DM, as well as on prevention, therapeutic management and prognosis of TB-DM.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmacokinetics
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
Address
Keppel Street
WC1E 7HT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 864 577,60
Administrative Contact
Chris Andrews (Mr.)

Participants (11)

STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 728 703
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 485 115
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert Golinski (Dr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 373 080
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emiel Schaap (Mr.)
STELLENBOSCH UNIVERSITY
South Africa
EU contribution
€ 713 040,80
Address
Victoria Street Administration B Building
7600 Stellenbosch
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Walzl (Prof.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 198 242
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Melanie Monteiro (Ms.)
UNIVERSITY OF OTAGO
New Zealand
EU contribution
€ 306 828
Address
Saint David Street
9054 Dunedin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colin Campbell-Hunt (Prof.)
UNIVERSITATEA DE MEDICINA SI FARMACIE DIN CRAIOVA
Romania
EU contribution
€ 487 063
Address
Petru Rares 2
200349 Craiova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mihai Caragea (Mr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 395 454,40
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna M. Van Apeldoorn (Mrs.)
UNIVERSIDAD PERUANA CAYETANO HEREDIA
Peru
EU contribution
€ 401 311,20
Address
Honorio Delgado 430
31 Lima
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Rivera (Dr.)
UNIVERSITAS PAJAJARAN
Indonesia
EU contribution
€ 747 781
Address
Jalan Raya Bandung Sumedang Km 21
45363 Sumedang
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bachti Alisjahbana (Dr.)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 297 300
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hannah Weber (Ms.)