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SYSTEMS BIOLOGY OF PATHWAYS INVOLVING BRAIN AGEING

Objective

In spite of valuable approaches applied to get a broad understanding of genetic, epidemiologic and molecular and system-level biological principles of human aging, cognitive decline remains as one of the greatest health challenges of the old age, with nearly 50% of adults over 85 afflicted of Alzheimer’s disease. Furthermore, drug development has not performed as expected in clinical trials, at least in part because of an insufficient mechanistic understanding at the systemic level in human. AgedBrainSYSBIO is a timely and straightforward project based on the integration of available transcriptomics, proteomics and metabolomics data, addition of relevant novel sets of data, their modeling and experimental testing in both human, mouse and drosophila. The concept is to identify subsets of pathways with two unique druggable hallmarks: (i) the validation of interactions occurring locally in subregions of neurons and (ii) a human and/or primate accelerated evolutionary signature, using six interacting approaches: (1) the identification of interacting protein networks from recent Late-Onset Alzheimer Disease- Genome Wide Association Studies (LOAD-GWAS) data, (2) the experimental validation of interconnected networks working in subregion of a neuron (such as dendrites and dendritic spines), (3) the inclusion of these experimentally validated networks in larger networks obtained from available databases to extend possible protein interactions, (4) the identification of human and/or primate positive selection either in coding or in regulatory gene sequences,(5) the manipulation of these human and/or primate accelerated evolutionary interacting proteins in human neurons derived from induced Pluripotent Stem Cells (iPSCs) and modeling prediction challenged in drosophila and novel mouse transgenic models. This work will finally allow (6) the validation of new druggable targets and markers as a proof-of-concept towards the prevention and cure of aging cognitive defects.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 575 445
Administrative Contact
Marianna Aurousseau (Mrs.)

Participants (14)

VIB VZW
Belgium
EU contribution
€ 486 500
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 300 000
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
Administrative Contact
Fabienne Jean (Dr.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 518 000
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Steve Brooks (Dr.)
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 671 500
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Doris Neubert (Ms.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 338 000
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
HYBRIGENICS SA
France
EU contribution
€ 630 611
Address
Impasse Reille 3-5
75014 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guillaume Floch (Mr.)
OU QURETEC
Estonia
EU contribution
€ 463 520
Address
Ulikooli 6A
51003 Tartu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Margus Jäger (Mr.)
GENE BRIDGES GMBH
Germany
EU contribution
€ 355 200
Address
Im Neuenheimer Feld 584
69120 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sigrid Brümmer (Mrs.)
reMYND NV
Belgium
EU contribution
€ 258 840
Address
Gaston Geenslaan 1
3001 Leuven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert De Jonge (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 208 231
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Tom Ratcliff (Mr.)
SIB SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
EU contribution
€ 458 270
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
Administrative Contact
Jocelyne Bocquet (Ms.)
THE BABRAHAM INSTITUTE
United Kingdom
EU contribution
€ 262 034
Address
Babraham Hall
CB22 3AT Cambridge
Activity type
Research Organisations
Administrative Contact
Fang Gao (Mrs.)
INSERM - TRANSFERT SA
France
EU contribution
€ 342 689
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)
NEUROSERVICE
France
EU contribution
€ 131 160
Address
Domaine De Saint Hilaire 595 Rue Pierre Berthier
13593 Aix En Provence
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bénédicte Rioche (Mrs.)