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Engineering Solutions for Back Pain: Simulation of Patient Variance

Objective

Back pain affects eight out of ten adults during their lifetime. It a huge economic burden on society, estimated to cost as much as 1-2% of gross national product in several European countries. Treatments for back pain have lower levels of success and are not as technologically mature as those for other musculoskeletal disorders such as hip and knee replacement. This application proposes to tackle one of the major barriers to the development of better surgical treatments for back pain.
At present, new spinal devices are commonly assessed in isolation in the laboratory under standardised conditions that do not represent the variation across the patient population. Consequently many interventions have failed during clinical trials or have proved to have poor long term success rates.
Using a combination of computational and experimental models, a new testing methodology will be developed that will enable the variation between patients to be simulated for the first time. This will enable spinal implants and therapies to be more robustly evaluated across a virtual patient population prior to clinical trial. The tools developed will be used in collaboration with clinicians and basic scientists to develop and, crucially, optimise new treatments that reduce back pain whilst preserving the unique functions of the spine.
If successful, this approach could be translated to evaluate and optimise emerging minimally invasive treatments in other joints such as the hip and knee. Research in the spine could then, for the first time, lead rather than follow that undertaken in other branches of orthopaedics.

Field of science

  • /medical and health sciences/clinical medicine/orthopaedics

Call for proposal

ERC-2012-StG_20111012
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

UNIVERSITY OF LEEDS
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 375 222,61
Principal investigator
Ruth Wilcox (Dr.)
Administrative Contact
Benjamin Williams (Mr.)

Beneficiaries (2)

UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 1 375 222,61
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Principal investigator
Ruth Wilcox (Dr.)
Administrative Contact
Benjamin Williams (Mr.)
THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST
United Kingdom
EU contribution
€ 123 554,39
Address
St James's University Hospital, Beckett Street
LS9 7TF Leeds
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Samatha Hood (Ms.)