Dynamic Combinatorial Chemistry is a new method with great potential for the development of new synthetic receptors, the discovery of new ligands for proteins and for studying the folding of extended molecules. The present proposal brings together most of the European groups with an active interest in these areas. The scientific aims are to further develop the underlying chemistry and the theory behind complex equilibrium systems and to deliver new functional molecules in the form of inhibitors of proteins, enantioselective synthetic receptors or catalysts. We will work towards these aims through a concerted and multidisciplinary approach calling on the complementary expertise of the participating research groups. This setting provides the ideal training ground for young researchers. The training programme will integrate different disciplines ranging from inorganic chemistry and computational chemistry to protein chemistry and nanotechnology.
In addition, the involvement of the biotech company Astex, who have an active interest in dynamic combinatorial chemistry, will be mutually beneficial: Astex will be informed of the latest developments in the field, while the students will be exposed to the industrial perspective on Science in general and Dynamic Combinatorial Chemistry in particular. Through the combined and synergistic efforts of all participants we will deliver a new generation of highly trained researchers that will help to consolidate Europeas leading role in Dynamic Combinatorial Chemistry and develop this new and highly promising technique to its full potential.
Call for proposal
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