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Developing a stem cell based therapy to replace nephrons lost through reflux nephropathy

Objective

The aim of this project is to design a stem cell-based therapy to prevent end-stage renal disease caused by reflux nephropathy in children. The two main reasons to focus on this condition are that it is the major cause of kidney failure in children and young adults and secondly, the disease typically takes several years to reach end stage, allowing time for therapies to repair damage kidneys before they become completely non-functional. Recent advances in stem cell science and tissue engineering present an unprecedented opportunity to design a stem cell therapy for this clinical problem.
This project will investigate the properties of several different stem cell types (embryonic stem cells, kidney stem cells, amniotic fluid stem cells and mesenchymal stem cells) in order to determine which is most appropriate for the generation of functional kidney tissue. To do this, novel biomaterials will be designed that will provide a substrate both for the generation of kidney progenitor cells and for their transplantation.

Call for proposal

FP6-2005-MOBILITY-1
See other projects for this call

Funding Scheme

RTN - Marie Curie actions-Research Training Networks

Coordinator

THE UNIVERSITY OF LIVERPOOL
Address
The Foundation Building, 765 Brownlow Hill
Liverpool
United Kingdom

Participants (5)

UNIVERSITA DEGLI STUDI DI TORINO.
Italy
Address
Via Giuseppe Verdi 8
Torino
LEIBNIZ-INSTITUT FUER POLYMERFORSCHUNG DRESDEN E.V.
Germany
Address
Hohe Strasse 6
PF 120411 Dresden
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Address
Spitalgasse 23
Wien
THE UNIVERSITY OF EDINBURGH
United Kingdom
Address
Old College, South Bridge
Edinburgh
ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI"
Italy
Address
Via Eritrea, 62
Milano