CORDIS
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CORDIS

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To decipher the optimal management of systemic sclerosis

Objective

The current approach to diagnosis and management of the rare disease systemic sclerosis (SSc) is based on American College of Rheumatology criteria with low sensitivity and few validated recommendations for the therapy of the disease and its manifold organ manifestations. To overcome these shortcomings, the DeSScipher project will use the multinational, prospective and open EUSTAR (Scleroderma Trials and Research group of the European League Against Rheumatism) SSc cohort based on the established MEDSonline database which covers >30 data items and will evolve into a multimodular tool to answer step-by-step all immanent questions in a long-term setting according to the nature of the disease. The resulting progress will address functionally disabling manifestations affecting the hands (digital ulcers and arthritis), and compare the efficacy and safety of off-label drugs in the treatment of vital organ manifestations. Specifically, the DeSScipher project will evaluate (i) the utility of a combination of easy-to-perform clinical and laboratory investigations in combination with capillaroscopy for identifying SSc patients at risk for the development of digital ulcers at an early stage (ii) the prevention and treatment of digital ulcers and hand arthritis in order to improve long-term disability and quality of life, (iii) the efficacy of different immunosuppressive agents in attenuating or inhibiting pulmonary fibrosis, (iv) the optimal treatment options for reducing morbidity and mortality of pulmonary hypertension and severe heart disease in SSc. Based on the results of these observational trials, the DeSScipher project will develop evidence-based clinical guidelines for the future management of adult and juvenile SSc to be disseminated widely and rapidly to physicians and patients. Novel outcome measures will also be provided as a basis for future clinical trials.
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Coordinator

JUSTUS-LIEBIG-UNIVERSITAET GIESSEN

Address

Ludwigstrasse 23
35390 Giessen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 555 182,21

Administrative Contact

Christian Maarten Veldman (Dr.)

Participants (14)

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NOVAMEN SAS

France

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 550 206,80

UNIVERSITE PARIS DESCARTES

France

EU Contribution

€ 110 224

UNIVERSITA DEGLI STUDI DI FIRENZE

Italy

EU Contribution

€ 104 440

UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI

Italy

EU Contribution

€ 185 840

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 170 919,49

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 218 070,80

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 502 795,30

PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS

Hungary

EU Contribution

€ 152 520

UNIVERSITY OF LEEDS

United Kingdom

EU Contribution

€ 168 998

NEW-WIN AG

Switzerland

EU Contribution

€ 121 500

FEDERATION OF EUROPEAN SCLERODERMA ASSOCIATIONS AISBL

Belgium

EU Contribution

€ 36 978,40

IVAN FOELDVARI

Germany

EU Contribution

€ 32 240

ACIES Consulting Group SAS

France

EU Contribution

€ 89 920

Project information

Grant agreement ID: 305495

Status

Closed project

  • Start date

    1 December 2012

  • End date

    30 November 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 791 344,57

  • EU contribution

    € 2 999 835

Coordinated by:

JUSTUS-LIEBIG-UNIVERSITAET GIESSEN

Germany