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Consortium on Organ Preservation in Europe

Consortium on Organ Preservation in Europe

Objective

The discrepancy between organ supply and demand remains the biggest challenge facing the transplant community today. In order to increase the amount of available donor organs, transplant specialists are increasingly turning to sub-optimal donor organs. Organs from such donors, usually have normal or near normal function before death, but retrieval, storage and transplantation cause progressive injury to the organ. Injury is predominantly caused by inadequate or absent delivery of oxygen and nutrients, either in the warm or cold preservation environment.
New techniques to improve organ preservation are being developed and the COPE consortium including:
• Normothermic liver machine perfusion (NMP)
• Hypothermic kidney machine perfusion (HMP)
• Novel additives for preservation solutions
These strategies are all directed to the vital period that starts at the time of circulatory arrest and extends to the point of transplantation. Specifically, they will tackle the following challenges:
• Exposure of donor organs to ischaemic injury whilst the organs remain in the donor.
• Progressive deterioration of the organ during conventional organ preservation.
• Repair of the organ during preservation using perfusate and pharmacological interventions.
• Identification of reliable predictors of organ viability using biological and other pre-transplant parameters.
The COPE consortium is the official organ preservation task force of ESOT and consists of a number of
European transplantation centers, front running transplantation research groups and a number of SMEs involved in developing perfusion fluids and technology. Together, they will be able to generate the statistical power and protocols necessary to test, validate and promote these new organ preservation techniques and increase the number of available solid donor organs.

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Address

Wellington Square University Offices
Ox1 2jd Oxford

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 066 282,59

Administrative Contact

Gill Wells (Ms.)

Participants (14)

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ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 578 726,62

UNIVERSITAETSKLINIKUM ESSEN

Germany

EU Contribution

€ 445 072,82

UNIVERSITAETSKLINIKUM BONN

Germany

EU Contribution

€ 180 206,39

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

France

EU Contribution

€ 4 000

UNIVERSITE DE POITIERS

France

EU Contribution

€ 405 684

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 434 773,57

SERVICIO MADRILENO DE SALUD

Spain

ORGANOX LIMITED

United Kingdom

EU Contribution

€ 633 235,95

ORGAN ASSIST PRODUCTS BV

Netherlands

EU Contribution

€ 613 200

AQIX LTD

United Kingdom

EU Contribution

€ 39 744

HEMARINA SA

France

EU Contribution

€ 72 156

EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION

Netherlands

EU Contribution

€ 20 000,40

MED-ASSIST BV

Netherlands

EU Contribution

€ 452 961,06

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Spain

EU Contribution

€ 44 799,60

Project information

Grant agreement ID: 305934

Status

Closed project

  • Start date

    1 January 2013

  • End date

    30 June 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 847 753,15

  • EU contribution

    € 5 990 843

Coordinated by:

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom