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Modelling properties, interactions, toxicity and environmental behaviour of engineered nanoparticles

Objective

"Nanotechnology is rapidly expanding. However, some types of engineered nanoparticles can be toxic for living organisms and exhibit negative impact on the environment. Thus, the design of new nanomaterials must be supported by a rigorous risk analysis. Following the recommendations by the EU REACH system and regarding ethical aspects, the risk assessment procedures should be performed with possible reduction of living animal use. The main objective of the NanoPuzzles project is to create new computational methods for comprehensive modelling the relationships between the structure, properties, molecular interactions and toxicity of engineered nanoparticles. The methods will be based on the Quantitative Structure - Activity Relationship approach, chemical category formation and read-across techniques. Those methods have been widely used in risk assessment of other groups of priority chemicals. But, because of some specific reasons, they can not be applied directly to nanoparticles. We will be developing novel methods within four complimentary areas (""puzzles""), namely: (i) evaluation of physico-chemical and toxicological data available for nanoparticles (NanoDATA), (ii) developing novel descriptors of nanoparticles' structure (NanoDESC), (iii) investigating interactions of nanoparticles with biological systems (NanoINTER), and (iv) quantitative structure - activity relationships modelling (NanoQSAR). Developed methods will be tested and verified for their technical viability by the collaborating industry representative. By implementing the NanoPuzzles methods, extensive animal testing would be significantly reduced. Moreover, the project will deliver the basis for categorising nanoparticles based on potential exposure, phys-chem, structural and toxicological properties. To maximise its impact, the project is going to cooperate with ModNanoTox, NanoTransKinetics, NanoSafety Cluster and NanoMedicine ETP."

Call for proposal

FP7-NMP-2012-SMALL-6
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIWERSYTET GDANSKI
Address
Ul. Bazynskiego 8
80309 Gdansk
Poland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 228 500
Administrative Contact
Tomasz Puzyn (Dr.)

Participants (4)

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 227 200
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
ETHNIKO IDRYMA EREVNON
Greece
EU contribution
€ 211 110
Address
Vas Konstantinou 48
11635 Athina
Activity type
Research Organisations
Administrative Contact
Ioanna Petrohilou (Ms.)
LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom
EU contribution
€ 195 200
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrew Young (Prof.)
INNOBALTICA SP ZOO
Poland
EU contribution
€ 114 800
Address
Ul. Trzy Lipy 3
80 172 Gdansk
Activity type
Research Organisations
Administrative Contact
Katarzyna Dembowska (Mrs.)