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Co-morbidity in relation to Aids

Objective

Persons with HIV on combination antiretroviral therapy (cART) are at increased risk of the premature development of age-associated non-communicable comorbidities (AANCC), including cardiovascular, chronic kidney, liver and pulmonary disease, diabetes mellitus, osteoporosis, non-AIDS associated malignancies, and neurocognitive impairment. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated ageing. The underlying pathogenesis is likely to be multifactorial and include sustained immune activation, both systemically and within the central nervous system.
By building on an established infrastructure for conducting longitudinal HIV cohort studies in Amsterdam and London, we will provide a detailed, prospective evaluation of AANCC among HIV-infected patients suppressed on cART and appropriately chosen and comparable non-infected controls. In this way, we will provide a robust estimate of the effect of treated HIV infection on the prevalence, incidence and age of onset of AANCC, thus clearly establishing a link between HIV and AANCC.
Through the “Human Immune System” (HIS) mouse model, experimental studies will permit us to differentiate the effects of HIV and cART on metabolic outcomes when applied under controlled conditions, thereby further elucidating the causative nature of the link between HIV and AANCC.
To further clarify potential pathogenic mechanisms underlying this causative link, including the possible induction of an inflammation-associated accelerated ageing phenotype, biomarkers which reflect each of these mechanisms will be investigated in biomaterial obtained from HIS mice and humans, and subsequently validated in patients with HIV on cART.
The successful execution of the experimental and clinical research outlined in this proposal will be ensured through a strong interdisciplinary collaboration between clinical, basic and translational scientists bridging the fields of HIV, AANCC and ageing.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Friso Janssen (Mr.)
EU contribution
€ 2 175 290,40

Participants (11)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 792 222,50
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 116 605,10
Address
Vasaparken
405 30 Goeteborg

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellen Rydberg (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 312 595,10
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Malgorzata Kielbasa (Ms.)
STICHTING RADBOUD UNIVERSITEIT
Netherlands
EU contribution
€ 180 870
Address
Houtlaan 4
6525 XZ Nijmegen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 491 387,60
Address
Via Zamboni 33
40126 Bologna

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Verdiana Bandini (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 127 507,50
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
M.A.J. Van Zeijl (Mrs.)
VIB VZW
Belgium
EU contribution
€ 190 637,50
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
GEMEENTE AMSTERDAM
Netherlands
EU contribution
€ 256 095,60
Address
Amstel 1
1011 PN Amsterdam

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Maria Prins (Prof.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU contribution
€ 41 040
Address
Via Universita 4
41121 Modena

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erica Villa (Prof.)
STICHTING HIV MONITORING
Netherlands
EU contribution
€ 15 360
Address
Meibergdreef 9
1105 AZ Amsterdam

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Activity type
Research Organisations
Administrative Contact
Frank De Wolf (Prof.)
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 299 146,80
Address
Universitatsstrasse 10
78464 Konstanz

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christina Leib-Kessler (Ms.)