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Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation

Objective

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:

• Develop a series of mutant alleles for every gene in the mouse genome
• Determine the phenotypic consequences of each mutation
• Identify mouse models for the complete disease spectrum in humans

To further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. To this effect, the Infrafrontier-I3 project brings together the leading European centers for systemic phenotyping of mouse mutants and the European Mouse Mutant Archive network. The Infafrontier-I3 partners aim to meet the future challenges presented by phenotyping, archiving and disseminating mouse models in the ERA as follows:

• Contribute to resource development by archiving of 1215 new mouse mutant lines
• Provide free of charge Transnational Access to mouse production and 1st line phenotyping capacities
• Offer a specialized axenic service to produce, maintain and to distribute germ-free mice
• Provide user friendly accession of Infrafrontier services, extensive manual data curation and cross referencing with other mouse database
• Improve user services by developing novel phenotyping and cryopreservation SOPs and by refining innovative research instrumentation
• Engage with the user community using a wide range of PR activities, a dedicated user meeting and an industry liaison workshop
• Offer state of the art cryopreservation and phenotyping training courses
• Benchmark Infrafrontier services with other major repositories

The comprehensive physical and data resources that will be generated by Infrafrontier-I3 will contribute to link basic biomedical research to medical applications and thereby drive innovation and support the Europe 2020 Strategy.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /social sciences/sociology/governance/public services

Call for proposal

FP7-INFRASTRUCTURES-2012-1-RTD
See other projects for this call

Funding Scheme

CP-CSA-Infra - Combination of CP and CSA

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Germany
Activity type
Research Organisations
EU contribution
€ 1 879 671,36
Administrative Contact
Jürgen Ertel (Dr.)

Participants (23)

MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 1 254 269,84
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Gates Hilary (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 709 029,53
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Glauco Pasquale Tocchini-Valentini (Prof.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 1 001 423
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
Administrative Contact
Steve Brooks (Dr.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 889 031,09
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Greece
EU contribution
€ 390 576,42
Address
Fleming Street 34
16672 Vari-athens
Activity type
Research Organisations
Administrative Contact
George Kollias (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 338 400
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Gipperth (Ms.)
FUNDACAO CALOUSTE GULBENKIAN
Portugal
EU contribution
€ 312 939,60
Address
Avenida Berna 45
1000 Lisboa
Activity type
Research Organisations
Administrative Contact
José Mário Leite (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 504 787,28
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Patrice Soullié (Mr.)
UNIVERSIDAD AUTONOMA DE BARCELONA
Spain
EU contribution
€ 50 500
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francisca Rabadán Sotos (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 533 470
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Alberto Sereno álvarez (Prof.)
OULUN YLIOPISTO
Finland
EU contribution
€ 396 269
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arto Eljander (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 554 999,59
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Gabriele Picarella (Mr.)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 18 000
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Michael Strätz (Dr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 18 000
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
Czechia
EU contribution
€ 380 793,60
Address
Videnska 1083
142 20 Praha 4
Activity type
Research Organisations
Administrative Contact
Radislav Sedlacek (Prof.)
VETERINAERMEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 394 092,62
Address
Veterinaerplatz 1
1210 Vienna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Rülicke (Prof.)
Toronto Centre for Phenogenomics Inc.
Canada
Address
Orde Street 25
M5T 3H7 Toronto
Activity type
Research Organisations
Administrative Contact
Colin Mckerlie (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 20 500
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Claire Guichard (Mrs.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 18 000
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 18 000
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Administrative Contact
Henri Van Luenen (Dr.)
TSE SYSTEMS GMBH
Germany
EU contribution
€ 169 247,07
Address
Siemenstrasse 21
61352 Bad Homburg Vor Der Hohe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans-Peter Engler
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 18 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah Malevé (Ms.)
INFRAFRONTIER GMBH
Germany
EU contribution
€ 30 000
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Raess (Dr.)