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Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation

Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation

Objective

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:

• Develop a series of mutant alleles for every gene in the mouse genome
• Determine the phenotypic consequences of each mutation
• Identify mouse models for the complete disease spectrum in humans

To further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. To this effect, the Infrafrontier-I3 project brings together the leading European centers for systemic phenotyping of mouse mutants and the European Mouse Mutant Archive network. The Infafrontier-I3 partners aim to meet the future challenges presented by phenotyping, archiving and disseminating mouse models in the ERA as follows:

• Contribute to resource development by archiving of 1215 new mouse mutant lines
• Provide free of charge Transnational Access to mouse production and 1st line phenotyping capacities
• Offer a specialized axenic service to produce, maintain and to distribute germ-free mice
• Provide user friendly accession of Infrafrontier services, extensive manual data curation and cross referencing with other mouse database
• Improve user services by developing novel phenotyping and cryopreservation SOPs and by refining innovative research instrumentation
• Engage with the user community using a wide range of PR activities, a dedicated user meeting and an industry liaison workshop
• Offer state of the art cryopreservation and phenotyping training courses
• Benchmark Infrafrontier services with other major repositories

The comprehensive physical and data resources that will be generated by Infrafrontier-I3 will contribute to link basic biomedical research to medical applications and thereby drive innovation and support the Europe 2020 Strategy.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Address

Ingolstadter Landstrasse 1
85764 Neuherberg

Germany

Activity type

Research Organisations

EU Contribution

€ 1 879 671,36

Administrative Contact

Jürgen Ertel (Dr.)

Participants (23)

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MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 1 254 269,84

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 709 029,53

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

EU Contribution

€ 1 001 423

GENOME RESEARCH LIMITED

United Kingdom

EU Contribution

€ 889 031,09

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

Greece

EU Contribution

€ 390 576,42

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 338 400

FUNDACAO CALOUSTE GULBENKIAN

Portugal

EU Contribution

€ 312 939,60

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 504 787,28

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

EU Contribution

€ 50 500

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 533 470

OULUN YLIOPISTO

Finland

EU Contribution

€ 396 269

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 554 999,59

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH

Germany

EU Contribution

€ 18 000

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 18 000

USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE

Czechia

EU Contribution

€ 380 793,60

VETERINAERMEDIZINISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 394 092,62

Toronto Centre for Phenogenomics Inc.

Canada

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 20 500

TEL AVIV UNIVERSITY

Israel

EU Contribution

€ 18 000

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

EU Contribution

€ 18 000

TSE SYSTEMS GMBH

Germany

EU Contribution

€ 169 247,07

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 18 000

INFRAFRONTIER GMBH

Germany

EU Contribution

€ 30 000

Project information

Grant agreement ID: 312325

Status

Closed project

  • Start date

    1 January 2013

  • End date

    31 December 2016

Funded under:

FP7-INFRASTRUCTURES

  • Overall budget:

    € 12 431 663,54

  • EU contribution

    € 9 900 000

Coordinated by:

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany