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Rational molecular Assessments and Innovative Drug Selection

Objective

Cervical cancer (CC) is the second most common cause of cancer deaths in women worldwide. The main objective of the RAIDs project is to use this model system which is accessible to repeat biopsies to learn how to stratify patients into targeted therapies. The patients’ tumors will be classified into molecular subtypes based on their molecular profile by use of high-throughput technologies (sequencing, RPPA) combined with integrative bioinformatics analysis. Stratification is a learning process which will need constant readaptation. It will rely on prognostic and predictive biomolecular information gained from patients who will receive either standard therapy (the cognitive cohort) or patients who receive (first generation) targeted therapy. Bioinformatics will be an essential tool to allow integrative genome/proteome analysis and provide functional interpretation of the results at each step. Machine learning techniques will be used to select the most reliable biomarkers. These tools will be used to predict response to cc treatment or progression. Moreover, systems biology approaches will be used to unravel the gene regulatory networks and signaling pathways involved in the tumor progression and should be helpful to select predictive biomarkers and putative drug targets.
Tumor material will be sampled before and following standard therapy or therapeutic HPV vaccination and/or novel targeted drug treatments. Clinical annotation by imaging methods as well as through biomarkers will have quality control procedures and relevant statistical models will be applied.
RAIDS is a multidisciplinary approach integrating genomic studies, protein arrays, viral genotyping and immunohistochemical investigations on CC cells and tissues between academic clinical centers and SME’s .
The project is expected to provide new tools for early diagnosis and targeted treatments exploited by SMEs and to accelerate innovation of CC therapy and improve quality of life.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Coordinator

INSTITUT CURIE
Address
Rue D'ulm 26
75231 Paris
France

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Activity type
Research Organisations
Administrative Contact
Maud Kamal (Dr.)
EU contribution
€ 1 651 811,20

Participants (17)

AMSTERDAM BIOTHERAPEUTICS UNIT
Netherlands
EU contribution
€ 723 630
Address
Louwesweg 6
1066EC Amsterdam

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Activity type
Research Organisations
Administrative Contact
Bastiaan Nuijen (Dr.)
SEQOMICS BIOTECHNOLOGIA KORLATOLT FELELOSSEGU TARSASAG
Hungary
EU contribution
€ 957 200
Address
Vallalkozok Utja 7
6782 Morahalom

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Attila Kereszt (Dr.)
Keocyt SAS

Participation ended

France
Address
Rue Chauvelot 29
92240 Malakoff

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christophe Pasik (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 281 466,36
Address
Rue De Tolbiac 101
75654 Paris

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Activity type
Research Organisations
Administrative Contact
Celia Farge (Ms.)
STICHTING ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Participation ended

Netherlands
Address
Plesmanlaan 121
1066CX Amsterdam

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Activity type
Research Organisations
Administrative Contact
Jan Van Den Ham (Mr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 372 134,40
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Selma Selma Ablak-Ergisi (Mrs.)
KLINIKEN ESSEN-MITTE EVANG. HUYSSENS-STIFTUNG/KNAPPSCHAFT GEMEINNUTZIGE GMBH
Germany
EU contribution
€ 28 936,95
Address
Henricistrasse 92
45136 Essen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Kurzeder (Dr.)
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 23 370,70
Address
Domstrasse 11
17489 Greifswald

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Voelker (Dr.)
INSTITUT ZA ONKOLOGIJU VOJVODINE-ONCOLOGY INSTITUTE OF VOJVODINA IOV
Serbia
EU contribution
€ 122 352,40
Address
Put Doktora Goldmana 4
21204 Sremska Kamenica

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Activity type
Research Organisations
Administrative Contact
Marina Popovic (Dr.)
TEO HEALTH SA
Romania
EU contribution
€ 6 810
Address
Iuliu Maniu 49 Corp Vechi
500019 Brasov

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eugeniu Banu (Dr.)
INSTITUTIA MEDICO-SANITARA PUBLICA INSTITUTUL ONCOLOGIC
Moldova
EU contribution
€ 60 645
Address
Strada Testemiteanu 30
2025 Chisinau

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Activity type
Research Organisations
Administrative Contact
Nina Samet (Dr.)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 545 692,80
Address
Rue Camille Desmoulins 39
94805 Villejuif

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Activity type
Research Organisations
Administrative Contact
Arnauld Forest (Mr.)
QUANTICSOFT SARL
France
EU contribution
€ 147 380,14
Address
Rue Du Cherche Midi 86
75006 Paris

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicolas De Saint Jorre (Mr.)
AYMING
France
EU contribution
€ 265 965,16
Address
Rue Chaptal 114
92300 Levallois-perret

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maud Bossard (Dr.)
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 537 572,80
Address
Plesmanlaan 121
1066 CX Amsterdam

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Activity type
Research Organisations
Administrative Contact
Jan Van Den Ham (Dr.)
HANNOVER CLINICAL TRIAL CENTER GMBH
Germany
EU contribution
€ 231 834,49
Address
Carl Neuberg Str 1 K 27 Oe 9751
30625 Hannover

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Fink (Mr.)
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
EU contribution
€ 42 840
Address
5 Rue Watt
75013 Paris

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Activity type
Research Organisations
Administrative Contact
Alicja Szofer-Araya (Mrs.)