Objective Background: Treatment of chronic diseases in the elderly with polypharmacy poses a threat to patient outcome and involves extensive costs. Little evidence exists regarding the benefits of polypharmacy, but rising evidence shows its harmful effects. Several approaches to reduce polypharmacy have been proposed, but none have been evaluated using clinically relevant endpoints.Aims: Based on a systematic review we will gather current best evidence and develop recommendations to optimize treatment of polymorbid elderly with cardiovascular disease, heart failure, hypertension, atrial fibrillation, diabetes mellitus type 2, musculoskeletal disorders, COPD, and mental diseases. We will then design an electronic decision support (eDS) tool incorporating the recommendations to be applied in primary care. The tool will be evaluated in a randomised controlled trial (RCT) to show that reduction of polypharmacy in the treatment of the target-diseases is beneficial and safe. Using the results of the RCT, the eDS-tool will be optimized and then disseminated for general utilization.Workplan: The project is scheduled for 4 years and will contain 12 work packages. WP1 comprises management of the project. The evidence regarding treatment of chronic diseases gathered within WP2 will be used to develop the eDS tool and an electronic case report form (eCRF) in WPs 3-4. After recruitment of surgeries and patients, and implementation of the tool in WP 5, the tool will be evaluated within a cluster-randomized controlled trial (WPs 6-10). The results of the RCT will be used to optimize the eDS tool (WP 11) which will then be disseminated (WP 12).Impact: The project will contribute to the EIP “Active and Healthy Ageing”. It will improve treatments suited to the needs of older people and lower health care costs by promoting standardized care and reducing hospital admissions. The tool will be exploited by one of the partners (Duodecim Medical Publications) to achieve widespread implementation Fields of science medical and health sciencesclinical medicinesurgerymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesbasic medicinepharmacology and pharmacyadverse drug reactions Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.2.2-2 - Investigator-driven clinical trials for optimisation of management of elderly patients with multiple diseases Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator Private Universitaet Witten/Herdecke gGmbH EU contribution € 1 219 644,35 Address Alfred-Herrhaussen Strasse 50 58455 Witten Germany See on map Region Nordrhein-Westfalen Arnsberg Ennepe-Ruhr-Kreis Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Sönnichsen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all KUSTANNUS OY DUODECIM Finland EU contribution € 885 126,10 Address Kalevankatu 20 00101 Helsinki See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ilkka Antero Kunnamo (Prof.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITATSMEDIZIN ROSTOCK Germany EU contribution € 658 950,90 Address SCHILLINGALLEE 35 18055 Rostock See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Rostock, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Attila Altiner (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SUDRITOLER AKADEMIE FUR ALLGEMEINMEDIZIN STIFTUNG ACCADEMIA ALTOATESINA DI MEDICINA GENERALE FONDAZIONE SAKAM ACAMG Italy EU contribution € 528 446,25 Address VIA DEI VANGA 18 39100 BOLZANO See on map Activity type Research Organisations Administrative Contact Giuliano Piccoliori (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 718 842,90 Address OXFORD ROAD M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Aneez Esmail (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG Austria EU contribution € 607 504,50 Address STRUBERGASSE 21 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Higher or Secondary Education Establishments Administrative Contact Tim Johansson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
