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Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia

Objective

Hematological diseases are highly heterogeneous malignancies in the matter of the molecular mechanisms related to their development and progression. A considerable heterogeneity can be further observed within the same hematological disease at the inter-individual level, being reflected by different clinical outcomes and responses to treatment in different patients. Nowadays, the advent of high-throughput next generation sequencing (NGS) technologies that are revolutionizing genomics and transcriptomics by providing a single base resolution tool for a unified deep analysis of diseases complexity allows a fast and cost-efficient fine-scale assessment of the genetic variability hidden within cohorts of patients affected by the same leukemia. That being so, by potentially highlighting inter-individual differences that may play a role in the differential success of diverse therapeutic interventions, they promise to be crucial for selecting the most appropriate medical treatments. This project aims at developing a European Hematological/NGS platform of scientists for improving outcomes for therapeutic interventions on acute and chronic leukemias and at developing strategies to personalize treatments and tailor therapies to different stratified groups of leukemia patients, with the goal of optimizing their efficacy and safety through a deeper and deeper understanding of the influence of genetic alterations on leukemias pathogenesis and treatment response (i.e. “personalized therapy”). Moreover, the final aim will be the identification of novel prognostic biomarkers for acute and chronic leukemias, as well as of molecular biomarkers and/or genome-wide profiles for the assessment of minimal residual disease. The originality of this project is to perform systematic deep whole exome/transcriptome studies on well-clinically-characterized leukemia patients, by exploiting NGS technologies able to quickly produce data with a good cost-effectiveness and an unprecedented resolution.

Field of science

  • /medical and health sciences/clinical medicine/cancer/leukemia

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Address
Via Zamboni 33
40126 Bologna
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 942 941,55
Administrative Contact
Valeria Genovesi (Dr.)

Participants (9)

UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 546 900
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Massimiliano Lauria (Dr.)
PERSONAL GENOMICS SRL
Italy
EU contribution
€ 795 719,10
Address
Via Roveggia 43
37136 Verona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Massimo Delledonne (Prof.)
SINAPTICA IT SRL
Italy
EU contribution
€ 499 400
Address
Via Collalto Sabino 20
00199 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marco Capoferri (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 449 600
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 500 002,71
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Myriam Witvrouw (Dr.)
FASTERIS SA
Switzerland
EU contribution
€ 549 400
Address
Chemin Du Pont Du Centenaire 109
1228 Plan Les Ouates
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laurent Farinelli (Dr.)
Masarykova univerzita
Czechia
EU contribution
€ 396 720
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katerina Pejchalova (Dr.)
FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA
Spain
EU contribution
€ 399 681,64
Address
Campus Miguel De Unamuno
37007 Salamanca
Activity type
Research Organisations
Administrative Contact
Antonio Mata Dominguez (Mr.)
MLL MUNCHNER LEUKAMIELABOR GMBH
Germany
EU contribution
€ 790 450
Address
Max Lebsche Platz 31
81377 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Torsten Haferlach (Prof.)