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Risk, Stem Cells and Tissue Kinetics – Ionising Radiation

Objective

The magnitude of cancer risk in humans exposed to low radiation doses (<100mSv) is uncertain and depends upon extrapolation of human population based estimates obtained at higher doses. The linear non-threshold extrapolation model currently used has some support from mechanistic/biophysical considerations but it is not based on understanding of the biological responses of the cells of origin for radiation cancer. Stem cells are widely recognised as the cells of origin for many cancers. Understanding the responses of stem cells to low radiation doses will be important therefore in providing mechanistic support for low dose cancer risk extrapolation. In this project, techniques emerging from stem cell biological and tissue kinetics research will be used to address several major areas of uncertainty in low dose (<100 mGy) cancer risk estimates:

1. The identification and enumeration of stem/progenitor cells at risk
2. Understanding low dose radio-sensitivity of stem cells and tissues.
3. Improving understanding of mechanisms of age-dependant cancer risk
4. Improving understanding of tissue specific differences in cancer risk.
5. Identification of key events and individual susceptibility factors associated with cancer development.

The primary output of the RISK-IR project will be peer reviewed scientific papers. Considerable efforts will be made to consolidate scientific evidence of relevance for radiation protection through reviews and dissemination of project results and implications to radiation protection specialists will be facilitated through a stakeholder meeting in the final year of the project.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-Fission-2012
See other projects for this call

Funding Scheme

CP - Collaborative project (generic)

Coordinator

Department of Health
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
United Kingdom
Activity type
Research Organisations
EU contribution
€ 1 292 548
Administrative Contact
Paul Barty (Mr.)

Participants (12)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 2 029 427
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Michele Martin (Dr.)
UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI
Italy
EU contribution
€ 344 400
Address
Viale Abramo Lincoln 5
81100 Caserta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Umberto Galderisi (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 294 295
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 622 520
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liesbeth Dorama (Ms.)
THE UNIVERSITY OF SUSSEX
United Kingdom
EU contribution
€ 481 035
Address
Sussex House Falmer
BN1 9RH Brighton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bettina Lehmbeck (Ms.)
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 399 244
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Dolores Liebanes (Dr.)
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
EU contribution
€ 23 251
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Phil Jones (Dr.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 391 800
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Panagiota Sotiropoulou (Dr.)
TECHNISCHE UNIVERSITAT DARMSTADT
Germany
EU contribution
€ 396 480
Address
Karolinenplatz 5
64289 Darmstadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Markus Lobrich (Prof.)
Public Health England an Executive Agency of the Dept of Health

Participation ended

United Kingdom
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Anne Dempsey (Mrs.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

Participation ended

United Kingdom
EU contribution
€ 122 210,38
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dimple Fernado (Mrs.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 287 789,62
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
Martin Dougherty (Dr.)