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Antibody-functionalised cardiovascular stents for improved biocompatibility and reduced restenosis

Objective

An industry-academia collaboration is proposed wherein two industry and three academic partners will establish a lasting, inter-national partnership for transfer of knowledge in biomaterials engineering. The partners have synergistic competences in the medical device sector, and, aided by a schedule of staff secondments and networking events, their relevant niche expertise will be shared and transferred intersectorally. In all 16 researchers will be supported.
Coronary artery disease accounts for two million deaths per year in Europe. The long-term outcome for patients is poor: 15% die or experience re-infarction within 30 days of initial diagnosis, while over 30% are re-hospitalised within 1 year. The estimated cost to the EU economy is €192 billion/year. The over-riding S&T objective of this collaboration is to develop a biomimetic cardiovascular stent prototype, by surface functionalisation with human antibody fragments, for improved coating by epithelial precursor cells in vivo. Sophisticated protein engineering and (nano)materials analysis from academic partners will interface with focused manufacturing and market experience of industry partners to deliver a stent with improved biocompatibility, reduced re-narrowing of arteries and superior clinical performance. Partners in interventional cardiology and industrial stent manufacturing will ensure clinical relevance and market-driven focus throughout design, development and post-project market entry.
The collaboration will develop skill sets of individual researchers, strengthen research capacity at partner institutions and support important extant biomedical device clusters in Ireland and Poland. The clinical end product will significantly improve patient outcomes and quality of life for Europe’s citizens; reduce costs for health care providers; and strengthen the European biomedical industry, leading to creation / retention of wealth in Europe and job creation in the European medical devices sector.

Call for proposal

FP7-PEOPLE-2012-IAPP
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Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 405 039,85
Administrative Contact
Mari Vahey (Ms.)

Participants (5)

POLITECHNIKA WROCLAWSKA
Poland
EU contribution
€ 159 330,32
Address
Wybrzeze Wyspianskiego 27
50-370 Wroclaw
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Halina Podbielska (Prof.)
BALTON SPOLKA ZOO
Poland
EU contribution
€ 299 011,16
Address
Nowy Swiat 7 M 14
00 496 Warszawa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
łukasz Wasyluk (Mr.)
ASHLAND SPECIALTIES IRELAND LIMITED

Participation ended

Ireland
EU contribution
€ 1 474
Address
National Science Park, Building V, Dublin Road, Petitswood
N91 F6PD Mullingar, Westmeath
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Colm O'dowd (Mr.)
UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
Poland
EU contribution
€ 159 330,32
Address
Ul Pasteura 1
50 367 Wroclaw
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wawrzynska Magdalena (Dr.)
UNIVERZITA KOMENSKEHO V BRATISLAVE
Slovakia
Address
Safarikovo Nam 6
814 99 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gustav Plesch (Prof.)