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WINTHERapeutics: development of a systems biology method to predict efficacy of cancer drugs to optimize individualized therapeutic decision and improve clinical outcome for cancer patients

Objective

Relevance: WINTHER project focuses on the development and validation, in 24 months, of industry supported new tools and computational methods, to predict efficacy of drugs in cancer patients
Current medical needs: Selection of cancer targeted therapies based on molecular abnormalities (mutations /amplifications/ translocations) benefit today only to 10-40% of patients. For the remaining majority, therapeutic decision is still based according to decade-old protocols with limited efficacy. Drug development depends on efficiency of clinical trials, with a staggering 95% failure rate

The objective: WINTHER proposes a fundamental change in trial design, through:
1. investigation of the tumour simultaneously with the normal matched tissue
2. development of a comprehensive database and genomic based algorithms and computational tools to predict the efficacy of drugs at individual level, in all patients, irrespective of cancer type
3. increase efficacy of therapeutics and clinical outcome,

Impact: Optimization of the portfolio of existing drugs and new compounds in clinical trials by matching the right drug to the right patient. In particular, it permits to avoid use of expensive drugs for patients that would not benefit from such treatments. WINTHER will made available to community as a clinically validated industry tool (website, database and algorithms) to assist clinicians in the analysis of genomic information based on the comparison of tumour and matched normal tissue and to increase the number of the patients to benefit from individualized rational selection of therapies.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

INSTITUT GUSTAVE ROUSSY
Address
Rue Camille Desmoulins 39
94805 Villejuif
France
Activity type
Research Organisations
EU contribution
€ 991 102
Administrative Contact
Arnauld Forest (Mr.)

Participants (10)

THE UNIVERSITY OF TEXAS SYSTEM
United States
EU contribution
€ 55 578
Address
Colorado Street 601
78701 2982 Austin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ollieta Nicholas (Mrs.)
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON
Spain
EU contribution
€ 147 952
Address
Calle Nazaret 115-117
08035 Barcelona
Activity type
Research Organisations
Administrative Contact
Alejandro Piris Gimenez (Dr.)
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel
EU contribution
€ 315 813
Address
Tel Hashomer Sheba Medical Center
52621 Ramat Gan
Activity type
Research Organisations
Administrative Contact
Aliza Ackerstein (Mrs.)
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 306 000
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dori Schneider (Ms.)
FOUNDATION MEDICINE INC
United States
EU contribution
€ 368 000
Address
Kendall Square 1 Suite B3501
02139 Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gary Palmer (Dr.)
ARIANA PHARMACEUTICALS SA
France
EU contribution
€ 440 496
Address
Rue Du Docteur Finlay 28
75015 Paris Cedex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Isabelle Chaduteau (Mrs.)
STICHTING SAGE BIONETWORKS EU
Netherlands
Address
Noorderakerweg 271 B
1069LT Amsterdam
Activity type
Other
Administrative Contact
Stephen H. Friend (Dr.)
WORLDWIDE INNOVATIVE NETWORK ASSOCIATION
France
EU contribution
€ 208 620
Address
Rue Edouard Vaillant 114
94800 Villejuif
Activity type
Other
Administrative Contact
Catherine Bresson (Mrs.)
Jewish General Hospital
Canada
EU contribution
€ 164 794
Address
3755 Chemin Cote Sainte Catherine
H3T 1E2 Montreal Qc
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Gustavo Wendichansky (Mr.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sentelle Eubanks