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Biomarkers of renal graft injuries in kidney allograft recipients

Objective

In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient treatment, quality of life and long-term graft survival. Also, there is an unmet need for better understanding of the immune and non-immune mechanisms of interstitial fibrosis /tubular atrophy and graft loss.
Combining all the skills required to build upon previous findings, BIOMARGIN will offer such opportunities in renal transplantation by integrating several omics approaches (mRNA, miRNA, peptides, proteins, lipids and metabolites) in blood, graft tissue and urine, in a well thought out, multistage discovery-to-validation translational programme, following the highest European ethics and regulatory requirements, as well as quality controls and quality assessments at all clinical and analytical steps. It is probably one of the first programmes to pursue such an integrated and systematic research approach.
BIOMARGIN aims to: (i) discover, select and validate blood and/or urine biomarkers of renal allograft lesions in adult and pediatric kidney transplant recipients; (ii) provide renal transplant physicians with non-invasive, robust diagnostic tests and interpretation algorithms enabling closer, more accurate, more predictive and/or less invasive monitoring of transplanted patients; (iii) help to avoid or diminish the use of biopsies and improve patient treatment, quality of life and long-term graft survival; (iv) help understand the mechanisms involved in the allograft injury processes which, combined with mass spectrometry imaging should offer pathologists new molecular targets and tools for renal graft biopsy analysis.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids
  • /medical and health sciences/clinical medicine/transplantation
  • /humanities/philosophy, ethics and religion/ethics
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 509 502
Administrative Contact
Muriel Bouas (Ms.)

Participants (12)

INSERM TRANSFERT SA
France
EU contribution
€ 455 400
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 305 820
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Agnès Dauvergne (Ms.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 455 576
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Philippe Lecestre (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 201 358
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Debisschop Véronique (Ms.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 748 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Ms.)
VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.
Belgium
EU contribution
€ 273 016
Address
Boeretang 200
2400 Mol
Activity type
Research Organisations
Administrative Contact
Ann Wevers (Ms.)
MOSAIQUES DIAGNOSTICS GMBH
Germany
EU contribution
€ 256 259
Address
Rotenburger Strasse 20
30659 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Annika Fricke (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 306 407
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Simone Hess (Ms.)
Cardinal Systems
France
EU contribution
€ 627 462
Address
Avenue De La République 91
Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Grégoire Lacroix (Mr.)
UNIVERSITE PARIS DESCARTES
France
EU contribution
€ 309 000
Address
Rue De L Ecole De Medecine 12
75270 Paris Cedex 06
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Valérie Hernu (Ms.)
AcureOmics AB
Sweden
EU contribution
€ 311 000
Address
Tvistevagen 48
SE-90187 Umeå
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Johan Trygg (Prof.)
Centre hospitalier universitaire de Limoges
France
EU contribution
€ 241 200
Address
Avenue Martin-luther-king 2
87000 Limoges
Activity type
Research Organisations
Administrative Contact
Anne Guerveno (Dr.)