CORDIS
EU research results

CORDIS

English EN

Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment

Project information

Grant agreement ID: 309329

Status

Closed project

  • Start date

    1 April 2013

  • End date

    31 March 2017

Funded under:

FP7-NMP

  • Overall budget:

    € 13 765 733,83

  • EU contribution

    € 10 000 000

Coordinated by:

TYOTERVEYSLAITOS

Finland

Objective

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced alterations in gene expression and translation, but may involve also epigenetic transformation of genetic functions. We believe that it will be possible to create a set of biomarkers of ENM toxicity that are relevant in assessing and predicting the safety and toxicity of ENM across species. The ENM-organism interaction is complex and depends, not simply on the composition of ENM core, but particularly on its physico-chemical properties. In fact, important physico-chemical properties are largely governed by their surface properties. All of these factors determine the binding of different biomolecules on the surface of the ENM, the formation of a corona around the ENM core. Thus, any positive or negative biological effect of ENM in organisms may be dynamically modulated by the bio-molecule corona associated with or substituted into the ENM surface rather than the ENM on its own. The bio-molecule corona of seemingly identical ENM cores may undergo dynamic changes during their passage through different biological compartments; in other words, their biological effects are governed by this complex surface chemistry. We propose that understanding the fundamental characteristics of ENM underpinning their biological effects will provide a sound foundation with which to classify ENM according to their safety. Therefore, the overarching objective of this research is to provide a means to develop a safety classification of ENM based on an understanding of their interactions with living organisms at the molecular, cellular, and organism levels based on their material characteristics.

Coordinator

TYOTERVEYSLAITOS

Address

Topeliuksenkatu 41 B
00250 Helsinki

Finland

Activity type

Research Organisations

EU Contribution

€ 1 766 304,79

Administrative Contact

Kai Savolainen (Prof.)

Participants (38)

IMS bordeaux

France

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 1 394 999,60

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 580 051

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Netherlands

EU Contribution

€ 244 894,75

UNIVERSITE DE BORDEAUX

France

EU Contribution

€ 250 000,40

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 5 433,88

UNIVERSITY OF PLYMOUTH

United Kingdom

EU Contribution

€ 414 064,80

HERIOT-WATT UNIVERSITY

United Kingdom

EU Contribution

€ 299 999,60

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE

Spain

EU Contribution

€ 365 000

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 464 100

INSTITUTE OF OCCUPATIONAL MEDICINE

United Kingdom

EU Contribution

€ 339 686,29

TURUN YLIOPISTO

Finland

EU Contribution

€ 249 999

TEKNOLOGIAN TUTKIMUSKESKUS VTT

Finland

EU Contribution

€ 50 986,14

ACONDICIONAMIENTO TARRASENSE ASSOCIACION

Spain

EU Contribution

€ 274 152

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 289 999,75

FONDAZIONE TELETHON

Italy

EU Contribution

€ 249 996,80

UNIVERSITAET LEIPZIG

Germany

EU Contribution

€ 250 000,40

EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT

Switzerland

EU Contribution

€ 290 000

BIOBYTE SOLUTIONS GMBH

Germany

EU Contribution

€ 150 000

INSIGHT PUBLISHERS LIMITED

United Kingdom

EU Contribution

€ 399 240

PLASMACHEM PRODUKTIONS- UND HANDEL GMBH

Germany

EU Contribution

€ 149 996

INKOA SISTEMAS SL

Spain

EU Contribution

€ 126 240

BIOTESYS GMBH

Germany

EU Contribution

€ 150 000

Zhejiang University

China

EU Contribution

€ 100 000

FUNDACAO UNIVERSIDADE DE BRASILIA

Brazil

EU Contribution

€ 100 000

NATIONAL HEALTH LABORATORY SERVICES

South Africa

EU Contribution

€ 80 000

NOORDWES-UNIVERSITEIT

South Africa

EU Contribution

€ 80 000

NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

United States

LEIDOS BIOMEDICAL RESEARCH INC

United States

NANOCYL SA

Belgium

EU Contribution

€ 19 040

NANOLOGICA AB

Sweden

EU Contribution

€ 20 000,40

UNIVERSITA DEGLI STUDI DI SALERNO

Italy

EU Contribution

€ 50 000

SOLVAY SA

Belgium

EU Contribution

€ 13 733,50

POLYMER FACTORY SWEDEN AB

Sweden

EU Contribution

€ 19 785

POLIMEROS Y SISTEMAS DE APLICACION TECNICA SL

Spain

EU Contribution

€ 19 880

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 244 566,12

MISVIK BIOLOGY OY

Finland

EU Contribution

€ 350 562,98

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 147 286,80

Project information

Grant agreement ID: 309329

Status

Closed project

  • Start date

    1 April 2013

  • End date

    31 March 2017

Funded under:

FP7-NMP

  • Overall budget:

    € 13 765 733,83

  • EU contribution

    € 10 000 000

Coordinated by:

TYOTERVEYSLAITOS

Finland