Objective The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced alterations in gene expression and translation, but may involve also epigenetic transformation of genetic functions. We believe that it will be possible to create a set of biomarkers of ENM toxicity that are relevant in assessing and predicting the safety and toxicity of ENM across species. The ENM-organism interaction is complex and depends, not simply on the composition of ENM core, but particularly on its physico-chemical properties. In fact, important physico-chemical properties are largely governed by their surface properties. All of these factors determine the binding of different biomolecules on the surface of the ENM, the formation of a corona around the ENM core. Thus, any positive or negative biological effect of ENM in organisms may be dynamically modulated by the bio-molecule corona associated with or substituted into the ENM surface rather than the ENM on its own. The bio-molecule corona of seemingly identical ENM cores may undergo dynamic changes during their passage through different biological compartments; in other words, their biological effects are governed by this complex surface chemistry. We propose that understanding the fundamental characteristics of ENM underpinning their biological effects will provide a sound foundation with which to classify ENM according to their safety. Therefore, the overarching objective of this research is to provide a means to develop a safety classification of ENM based on an understanding of their interactions with living organisms at the molecular, cellular, and organism levels based on their material characteristics. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesengineering and technologynanotechnologynano-materials Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2012.1.3-1 - Systematic investigations of the mechanisms and effects of engineered nanomaterial interactions with living systems and/or the environment Call for proposal FP7-NMP-2012-LARGE-6 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator TYOTERVEYSLAITOS EU contribution € 1 766 304,79 Address TOPELIUKSENKATU 41 B 00250 Helsinki Finland See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Kai Savolainen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (38) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE BORDEAUX I Participation ended France EU contribution No data Address 351 Cours de la Liberation 33405 TALENCE See on map Activity type Higher or Secondary Education Establishments Administrative Contact Katel Goeden (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 1 394 999,60 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Per-Olof Larsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland EU contribution € 580 051,00 Address BELFIELD 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Donal Doolan (Mr.) Links Contact the 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