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Novel nanotechnology-enabled system for endovascular in vivo near-infrared fluorescence molecular imaging and endovascular near-infrared targeted photodynamic therapy of atherosclerotic heart disease

Objective

CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:
1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up therapy monitoring of atherosclerotic coronary artery disease (CAD),
2) nonclinically evaluate this system,
3) clinically validate the system after regulatory approval, &
4) reduce in the long-term CAD deaths and morbidity by up to 40%, resulting in a significant decrease of the European and global healthcare costs for CAD, increasing the income of the European healthcare industry from CAD market which is the global largest. The CosmoPHOS-nano consortium has a five year history of successful collaboration between the industrial and academic partners, and its funding would underpin a team devoted to delivering a novel powerful & affordable healthcare solution against the leading cause of death, without the need for heavy and expensive medical equipment.
The CosmoPHOS system consists of two interacting components:
a) targeted theranostic near-infrared photoactivatable biocompatible nanomedicines, and
b) medical devices.
After systemic administration, the nanomedicines targeted accumulate in coronary atherosclerotic plaques, followed by endocoronary photoactivation and detection by the medical devices, enabling molecular imaging, targeted therapy, real-time & follow-up therapy monitoring of CAD. Preliminary in vitro & in vivo successful experimental results, as well as parts of the CosmoPHOS system are already available from the prior five year collaboration.
The project plan includes: A) nonclinical R&D (30 months); B) nonclinical validation & regulatory approval (18 months); C) first-in-man phase-I clinical trial in 20 CAD patients (12 months).

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /medical and health sciences/medical biotechnology/nanomedicine
  • /humanities/history and archaeology/history

Call for proposal

FP7-NMP-2012-LARGE-6
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ITA-SUOMEN YLIOPISTO
Address
Yliopistonranta 1 E
70211 Kuopio
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 029 689,65
Administrative Contact
Jaana Backman (Ms.)

Participants (18)

COSMOPHOS LTD
Greece
EU contribution
€ 499 540
Address
Adrianoupoleos 1A
55133 Thessaloniki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Panagiotis Trohopoulos (Dr.)
FREIE UNIVERSITAET BERLIN
Germany
EU contribution
€ 523 735
Address
Kaiserswerther Strasse 16-18
14195 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tanja Binder (Ms.)
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 679 426
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tomas Torres (Prof.)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 657 547
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Hörmann (Ms.)
Fujikura Europe Ltd
United Kingdom
EU contribution
€ 75 060
Address
C51 Barwell Business Park, Leatherhead Road
KT9 2NY Chessington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Rolph (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 844 768
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
FIBERTECH CO., LTD
Japan
Address
Kanda-nishiki-cho 3-23, Chiyoda-ku, Nishimoto Kosan Nishikicho Bldg 10F
101-0054 Tokyo Chiyoda-ku
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Keiko Nishimura (Ms.)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 210 652
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vilmos Ivády (Dr.)
TOXI-COOP TOXIKOLOGIAI KUTATO KOZPONT ZARTKORUEN MUKODO RT
Hungary
EU contribution
€ 500 275
Address
Magyar Jakobinusok Tere 4/B 5.Em.2.
1122 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gabor Hirka (Dr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 284 337,75
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin De Geest (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 310 088
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tine Heylen (Ms.)
BIOCONTRACT SP ZOO
Poland
EU contribution
€ 303 032
Address
Ulica Zambrowska 36
61051 Poznan
Activity type
Research Organisations
Administrative Contact
Andrzej Mackiewicz (Prof.)
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
EU contribution
€ 312 592,40
Address
Via Adamello 16
20139 Milano
Activity type
Research Organisations
Administrative Contact
Carlo Raimondi Cominesi (Mr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 328 120
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
United States
Address
Himes Hall 202
70803 Baton Rouge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Darya Courville (Ms.)
ETHNIKO IDRYMA EREVNON
Greece
EU contribution
€ 223 194
Address
Vas Konstantinou 48
11635 Athina
Activity type
Research Organisations
Administrative Contact
Ioanna Petrohilou (Mrs.)
EURAM LIMITED
United Kingdom
EU contribution
€ 374 400
Address
Lucy Tower Street Tower House
LN1 1XW Lincoln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nigel Lambert (Mr.)
POHJOIS-SAVON SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 346 895,20
Address
Pl 100
70029 Kys
Activity type
Research Organisations
Administrative Contact
Kirsi Luoto (Dr.)