Objetivo Catalytic C-H functionalization holds great promise as a tool to simplify the synthesis and modification of organic compounds. A complete set of C-H functionalization methodologies would allow the synthesis of most molecules of interest. Despite important advances in the last decades, major challenges remain, in particular, on how to control the regioselectivity of C-H activation amongst the many C-H bonds present in the molecule.The aim of the research activities detailed in this proposal is to develop a cascade process that will use CO2 as an invisible Directing Group leading to an array of novel direct meta-functionalization methodologies. Our new methodology will proceed through a multi-catalytic system where (a) CO2 is captured ortho to a group R, (b) a CO2H directed ortho-fuctionalization occurs, and (c) CO2 is removed leading to the product of meta-functionalization. Thus, this ground-breaking methodology will present enormous advantages respect to ‘traditional’ cross-couplings in terms of cost (cheaper starting materials), and waste generation (only water and carbon dioxide generated), becoming a remarkably greener approach to the synthesis of the important biaryl unit.Clearly, the development of a meta-selective C-H functionalization methodology with increased substrate scope would be highly desirable, improving the access to biaryl motifs, which are ubiquitous in natural products, pharmaceuticals and organic materials, offering a more direct, economic and significantly greener approach. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencesorganic chemistryhydrocarbonsnatural scienceschemical sciencescatalysis Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2012-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador QUEEN MARY UNIVERSITY OF LONDON Aportación de la UE € 221 606,40 Dirección 327 MILE END ROAD E1 4NS London Reino Unido Ver en el mapa Región London Inner London — East Tower Hamlets Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Igor Larrosa (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos