Obiettivo "The relationship between hemorrhagic shock, systemic inflammatory response syndrome, and multiple organ failure has long been investigated, but no accepted tissue injury mechanism has been assessed. This shortage of understanding of the basic pathophysiology limits the clinical management of one of the most important medical conditions from a mortality point of view, with implications in anesthesia and critical care.In this proposal, a new approach to the study of the molecular triggers of shock is proposed, on the basis of the innovative framework of the ""Autodigestion Hypothesis"". The goals are to identify the root cause of hemodynamic instability and specifically of shock induced acute heart failure, and to propose therapeutic countermeasures for its prevention and treatment.An animal model of hemorrhagic shock in the rat will be used for experimental induction of hemorrhage and resuscitation, with the aim of shedding light on the potential cleavage of important receptors in the heart due to the proteolytic action of digestive enzymes and matrix metalloproteinases.A multiscale approach to data analysis will be formulated to describe the pathogenesis of shock, from the cellular and molecular phenomena to its system wide symptoms, and to predict the occurrence of hemodynamic instability, hypotension and heart failure from the information conveyed by hemodynamic vital signs which are commonly accessible in critical care or emergency settings.The training implications of this project will enable the fellow to receive high level training on state-of-the-art molecular cardiovascular physiology and disease, and to complement his current skills in hemodynamic signal processing and modeling, granting him the opportunity to expand his current interests and background and to achieve a complete profile and independence as a researcher in the cardiovascular field." Campo scientifico natural sciencescomputer and information sciencesdata sciencemedical and health sciencesbasic medicinephysiologypathophysiologyengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsignal processingmedical and health sciencesclinical medicinecritical care medicinemedical and health sciencesclinical medicinecardiology Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2012-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2012-IOF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IOF - International Outgoing Fellowships (IOF) Coordinatore POLITECNICO DI MILANO Contributo UE € 261 627,60 Indirizzo PIAZZA LEONARDO DA VINCI 32 20133 Milano Italia Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Fabio Conti (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
