Objetivo Since living memory, the basic treatment strategies for the therapy of human diseases has not much changed conceptually. Although the molecular understanding of metabolic disorders continues to progress significantly the therapeutic strategy is still based on specific, often heterologous compounds which interfere with critical disease targets, trigger a metabolic bypass reaction or complement a molecular deficiency. As systems biology is revealing gene-function correlations and metabolic network dynamics at great pace and synthetic biology enables bottom-up de-novo design of genetic devices with predictable behaviour, time has now come to develop novel treatment strategies. Prosthetic genetic networks are expected to play a central part of such future treatment strategies. Prosthetic networks are synthetic sensor/effector devices or molecular prostheses which, upon integration into cells and functional connection to their metabolism, monitor disease-relevant metabolites, process off-level concentrations and coordinate adjusted diagnostic, preventive or therapeutic responses in a seamless, automatic and self-sufficient manner. Using a synthetic biology approach and capitalizing on our pioneering prosthetic network designed to control urate homeostasis and treat the tumour lysis syndrome as well as gouty arthritis, ProNet is a highly integrated, multiparallel and interdisciplinary effort to provide a series of prosthetic sensor/effector circuits for precise trigger-control of therapeutic transgenes. ProNet will focus on providing novel treatment opportunities for diabetes and obesity, two core pathologies of the metabolic syndrome, which is on its way to become the top epidemic of the 21st century. ProNet may provide new opportunities for the treatment strategies of the future thereby making the classic therapy of taking pills and getting injections in specified amounts and at particular times likely to become a thing of the past. Ámbito científico natural sciencesbiological sciencessynthetic biologyengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesmedical biotechnologyimplantsmedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS9 - ERC Advanced Grant - Applied life sciences and biotechnology Convocatoria de propuestas ERC-2012-ADG_20120314 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Aportación de la UE € 2 498 800,00 Dirección Raemistrasse 101 8092 Zuerich Suiza Ver en el mapa Región Schweiz/Suisse/Svizzera Zürich Zürich Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Martin Fussenegger (Prof.) Investigador principal Martin Anton Fussenegger (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Suiza Aportación de la UE € 2 498 800,00 Dirección Raemistrasse 101 8092 Zuerich Ver en el mapa Región Schweiz/Suisse/Svizzera Zürich Zürich Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Martin Fussenegger (Prof.) Investigador principal Martin Anton Fussenegger (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos